国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
4期
315-318
,共4页
MUC5AC%哮喘%慢性阻塞性肺疾病%弥漫性泛细支气管炎%支气管扩张%肺癌%肺囊性纤维化
MUC5AC%哮喘%慢性阻塞性肺疾病%瀰漫性汎細支氣管炎%支氣管擴張%肺癌%肺囊性纖維化
MUC5AC%효천%만성조새성폐질병%미만성범세지기관염%지기관확장%폐암%폐낭성섬유화
MUC5AC%Asthma%Chronic obstructive pulmonary disease%Diffuse panbronchiolitis%Bronchiectasis%Lung cancer%Cystic fibrosis
黏蛋白是由气道上皮杯状细胞和黏膜下层的黏液细胞分泌的一种高相对分子质量糖蛋白.MUC5AC作为气道黏液中最为重要的黏蛋白,起保护和润滑上皮作用,可防御外来具有生物活性的刺激物质,阻止细菌在气道植入和生长,参与上皮生长、更新和分化,细胞识别和信号传导等.众多研究表明,MUC5AC与肺部疾病如支气管哮喘、COPD、弥漫性泛细支气管炎、支气管扩张、肺癌、肺囊性纤维化等有着密切的关系.随着对其研究的深入,MUC5AC将有望成为新药作用的靶点,在肺部疾病的治疗方面发挥着重要作用.本文就MUC5AC的种类、结构、信号传导通路与肺部疾病的关系进行综述.
黏蛋白是由氣道上皮杯狀細胞和黏膜下層的黏液細胞分泌的一種高相對分子質量糖蛋白.MUC5AC作為氣道黏液中最為重要的黏蛋白,起保護和潤滑上皮作用,可防禦外來具有生物活性的刺激物質,阻止細菌在氣道植入和生長,參與上皮生長、更新和分化,細胞識彆和信號傳導等.衆多研究錶明,MUC5AC與肺部疾病如支氣管哮喘、COPD、瀰漫性汎細支氣管炎、支氣管擴張、肺癌、肺囊性纖維化等有著密切的關繫.隨著對其研究的深入,MUC5AC將有望成為新藥作用的靶點,在肺部疾病的治療方麵髮揮著重要作用.本文就MUC5AC的種類、結構、信號傳導通路與肺部疾病的關繫進行綜述.
점단백시유기도상피배상세포화점막하층적점액세포분비적일충고상대분자질량당단백.MUC5AC작위기도점액중최위중요적점단백,기보호화윤활상피작용,가방어외래구유생물활성적자격물질,조지세균재기도식입화생장,삼여상피생장、경신화분화,세포식별화신호전도등.음다연구표명,MUC5AC여폐부질병여지기관효천、COPD、미만성범세지기관염、지기관확장、폐암、폐낭성섬유화등유착밀절적관계.수착대기연구적심입,MUC5AC장유망성위신약작용적파점,재폐부질병적치료방면발휘착중요작용.본문취MUC5AC적충류、결구、신호전도통로여폐부질병적관계진행종술.
Mucins are high-molecular-weight glycoproteins secreted by airway epithelial goblet cells and submucosal mucous cells.As the most important airway mucin protein,MUC5AC can prevent the growth and implantation of bacteria in the airway,participate in the epithelial growth,renewal and differentiation,cell recognition and signal transduction.Many studies show that MUC5AC has great correlation with lung diseases such as asthma,chronic obstructive pulmonary disease,diffuse panbronchiolitis,bronchiectasis,lung cancer,and cystic fibrosis.With the deeper research,MUC5AC is expected to become a new drug target,plays an important role in the treatment of lung diseases.This article reviews the types,structure,signal transduction pathway of MUC5AC and the relationship of it with lung diseases.
