CAJ | 학술논문

目的探讨联合吸入沙美特罗替卡松及噻托溴铵对重度极重度稳定期COPD患者肺通气功能指标、活动耐力及生活质量的疗效观察.方法选取2008年1月至2010年2月河间市人民医院门诊收治的102例稳定期重度极重度COPD患者,采用完全随机法分成A、B、C 3组,A组给予噻托溴铵干粉剂,B组给予沙美特罗替卡松50/500 μg,C组给予噻托溴铵干粉剂与沙美特罗替卡松联合吸入,共治疗6个月,在治疗3个月和6个月时分别进行肺通气功能评定、运动耐力评定、健康相关生活质量评价.结果 3组患者治疗后肺通气功能评定、运动耐力评定、健康相关生活质量评价较治疗前均有改善,C组比A、B2组各指标改善明显,差异有统计学意义(P值均＜0.05).结论联合使用噻托溴铵和沙美特罗替卡松可以更好地改善重度极重度稳定期COPD患者肺通气功能、提高运动耐力及生活质量,且不良反应发生率低,值得临床推广.
목적 탐토연합흡입사미특라체잡송급새탁추안대중도겁중도은정기COPD환자폐통기공능지표、활동내력급생활질량적료효관찰.방법 선취2008년1월지2010년2월하간시인민의원문진수치적102례은정기중도겁중도COPD환자,채용완전수궤법분성A、B、C 3조,A조급여새탁추안간분제,B조급여사미특라체잡송50/500 μg,C조급여새탁추안간분제여사미특라체잡송연합흡입,공치료6개월,재치료3개월화6개월시분별진행폐통기공능평정、운동내력평정、건강상관생활질량평개.결과 3조환자치료후폐통기공능평정、운동내력평정、건강상관생활질량평개교치료전균유개선,C조비A、B2조각지표개선명현,차이유통계학의의(P치균＜0.05).결론 연합사용새탁추안화사미특라체잡송가이경호지개선중도겁중도은정기COPD환자폐통기공능、제고운동내력급생활질량,차불량반응발생솔저,치득림상추엄.
Objective The purpose of the study was to investigate the effect of tiotropium combined with salmeterol/fluticasone propionate in patients with severe to-very severe stable chronic obstructive pulmonary disease (COPD).Methods One hundred and two patients admitted for severe-tovery severe stable COPD from January 2008 to February 2010 were randotnly assigned to receive tiotropium alone (group A),salmeterol/fluticasone propionate (50/500 μg) alone (group B),and combination of tiotropium and salmeterol/fluticasone propionate (group C),respectively,for 6 months.All patients were assessed at months 3 and 6 for pulmonary with ventilation function,exercise tolerance and health-related quality of life.Results At both months 3 and 6,pulmonary ventilation function,exercise tolerance,and health-related quality of life were improved in all groups compared with pretreatment values.Moreover,significantly greater improvement of the three indicators was observed in group C than in groups A and B (all P ＜0.05).Conclusions The combination of tiotropium and salmeterol/fluticasone propionate was superior to any single-agent treatment in improving pulmonary ventilation function,exercise tolerance,and quality of life in patients with severe-to-very severe stable COPD,without additional adverse effects.Therefore,it should be encouraged in clinical practice.