国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
5期
351-353
,共3页
慢性阻塞性肺疾病%肺部感染%病原分析%治疗策略
慢性阻塞性肺疾病%肺部感染%病原分析%治療策略
만성조새성폐질병%폐부감염%병원분석%치료책략
Chronic obstructive pulmonary disease%Pulmonary infection%Pathogenic analysis%Treatment strategies
目的 研究COPD合并肺部感染(PI)病原分布及其治疗策略.方法 选择2010年4月至2012年12月我院收治的106例COPD合并PI患者作为观察对象,随机分为观察组和对照组,每组各53例.两组患者均进行痰培养以及药敏检测,参照痰培养及药敏实验结果对症用药,观察组在此基础上给予舒利迭吸入剂;对比两组不同方法用药疗效.结果 对患者进行痰培养并观察菌株分布情况,结果显示,两组患者感染菌种差异无统计学意义(x2=0.314,P＞0.05),且主要致病菌均为革兰阴性菌族(gram-negative bacterium,GNB)以及革兰阳性菌族(gram-positive bacterium,GPB).其中GNB为60.4％(64/106),GPB为32.1％(34/106),此外还有少数真菌6.60％(7/106).大部分GNB对于亚胺硫霉素比较敏感,其敏感率为81.3％,其次是丁胺卡那,敏感率为73.4％,最次为头孢他啶仅有3.13％.GPB对于万古霉素比较敏感,其敏感率为94.1％,其次为亚胺硫霉素,敏感率为88.2％.其中亚胺硫霉素对两种菌种敏感率均较高,分别为81.3％和88.2％.观察组有效率为96.22％(51/53),显著高于对照组的71.70％(38/53),差异有统计学意义(x2=11.840,P＜0.01).结论 在深部痰培养以及药敏实验的基础上对症治疗的同时,给予舒利迭吸入剂,可提高COPD合并PI的临床治疗疗效.
目的 研究COPD閤併肺部感染(PI)病原分佈及其治療策略.方法 選擇2010年4月至2012年12月我院收治的106例COPD閤併PI患者作為觀察對象,隨機分為觀察組和對照組,每組各53例.兩組患者均進行痰培養以及藥敏檢測,參照痰培養及藥敏實驗結果對癥用藥,觀察組在此基礎上給予舒利迭吸入劑;對比兩組不同方法用藥療效.結果 對患者進行痰培養併觀察菌株分佈情況,結果顯示,兩組患者感染菌種差異無統計學意義(x2=0.314,P＞0.05),且主要緻病菌均為革蘭陰性菌族(gram-negative bacterium,GNB)以及革蘭暘性菌族(gram-positive bacterium,GPB).其中GNB為60.4％(64/106),GPB為32.1％(34/106),此外還有少數真菌6.60％(7/106).大部分GNB對于亞胺硫黴素比較敏感,其敏感率為81.3％,其次是丁胺卡那,敏感率為73.4％,最次為頭孢他啶僅有3.13％.GPB對于萬古黴素比較敏感,其敏感率為94.1％,其次為亞胺硫黴素,敏感率為88.2％.其中亞胺硫黴素對兩種菌種敏感率均較高,分彆為81.3％和88.2％.觀察組有效率為96.22％(51/53),顯著高于對照組的71.70％(38/53),差異有統計學意義(x2=11.840,P＜0.01).結論 在深部痰培養以及藥敏實驗的基礎上對癥治療的同時,給予舒利迭吸入劑,可提高COPD閤併PI的臨床治療療效.
목적 연구COPD합병폐부감염(PI)병원분포급기치료책략.방법 선택2010년4월지2012년12월아원수치적106례COPD합병PI환자작위관찰대상,수궤분위관찰조화대조조,매조각53례.량조환자균진행담배양이급약민검측,삼조담배양급약민실험결과대증용약,관찰조재차기출상급여서리질흡입제;대비량조불동방법용약료효.결과 대환자진행담배양병관찰균주분포정황,결과현시,량조환자감염균충차이무통계학의의(x2=0.314,P＞0.05),차주요치병균균위혁란음성균족(gram-negative bacterium,GNB)이급혁란양성균족(gram-positive bacterium,GPB).기중GNB위60.4％(64/106),GPB위32.1％(34/106),차외환유소수진균6.60％(7/106).대부분GNB대우아알류매소비교민감,기민감솔위81.3％,기차시정알잡나,민감솔위73.4％,최차위두포타정부유3.13％.GPB대우만고매소비교민감,기민감솔위94.1％,기차위아알류매소,민감솔위88.2％.기중아알류매소대량충균충민감솔균교고,분별위81.3％화88.2％.관찰조유효솔위96.22％(51/53),현저고우대조조적71.70％(38/53),차이유통계학의의(x2=11.840,P＜0.01).결론 재심부담배양이급약민실험적기출상대증치료적동시,급여서리질흡입제,가제고COPD합병PI적림상치료료효.
Objective To study the pathogen distribution and treatment strategies of chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection (PI).Methods One hundred and six cases of COPD patients with PI from April 2010 to December 2012 in our hospital were selected as observation objects,and were randomly divided into observation group and control group,each group had 53 cases.Observation group were given sputum culture and drug sensitivity test,according to sputum culture and drug sensitive test results symptomatic medication.Control group according to the clinical experience with drugs.Compared two groups of different methods of drug efficacy.Results The patients were given sputum culture and observed the distribution,the results showed,the main pathogens were gram negative bacteria group (GNB) and gram positive bacteria group (GPB).GNB was 58.49％ (31/53) GPB was 33.96％ (18/53).Most of the GNB element was sensitive to imipenem mold,the sensitivity rate was 83.87 ％,followed byamikacin,the sensitivity rate was 74.19 ％,most of the time only was 3.23％ forceftazidime.GPB was sensitive to vancomycin,the sensitivity rate was 94.44％,followed by imipenem,the sensitivity rate was 88.89％.The imipenem against twostrains sensitive rate was higher,respectively was 83.87 ％,88.89 ％.Observation group was 96.22 ％ (51/53),significantly higher than control group of 71.70％ (38/53),the difference was statistically significant (x2 =11.840,P ＜0.01).Conclusions Sputum culture and drug sensitive test of deep,the corresponding drugs in the treatment of COPD with PI,have curative effect.
