国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
5期
354-359
,共6页
前列腺素D2%Th2细胞上表达的化学趋向性受体同种分子%前列腺素类受体%支气管哮喘%研究进展
前列腺素D2%Th2細胞上錶達的化學趨嚮性受體同種分子%前列腺素類受體%支氣管哮喘%研究進展
전렬선소D2%Th2세포상표체적화학추향성수체동충분자%전렬선소류수체%지기관효천%연구진전
Prostaglandin D2%Chemoattractant receptor homologous molecule expressed on Th2 cells%D prostanoid receptor%Bronchial asthma%Research progress
前列腺素D2 (prostaglandin D2,PGD2)是由支气管哮喘(简称哮喘)患者的肥大细胞等分泌的一种主要的前列腺素类物质.尽管它在哮喘发病机制中的作用尚不完全清楚.但大量研究表明PGD2通过相应受体介导参与哮喘的形成.最近,对于新型Th2细胞上表达的化学趋向性受体同种分子(chemoattractant receptor homologous molecule expressed on Th2 cells,CRTH2)受体的研究取得新进展,前列腺素类受体(d prostanoid receptor,DP)与CRTH2两者协同作用诱导炎症细胞迁移和细胞因子的产生,介导哮喘等过敏性疾病的发生发展过程.该篇主要综述PGD2及其受体CRTH2在哮喘发病中作用机制的最新研究进展.
前列腺素D2 (prostaglandin D2,PGD2)是由支氣管哮喘(簡稱哮喘)患者的肥大細胞等分泌的一種主要的前列腺素類物質.儘管它在哮喘髮病機製中的作用尚不完全清楚.但大量研究錶明PGD2通過相應受體介導參與哮喘的形成.最近,對于新型Th2細胞上錶達的化學趨嚮性受體同種分子(chemoattractant receptor homologous molecule expressed on Th2 cells,CRTH2)受體的研究取得新進展,前列腺素類受體(d prostanoid receptor,DP)與CRTH2兩者協同作用誘導炎癥細胞遷移和細胞因子的產生,介導哮喘等過敏性疾病的髮生髮展過程.該篇主要綜述PGD2及其受體CRTH2在哮喘髮病中作用機製的最新研究進展.
전렬선소D2 (prostaglandin D2,PGD2)시유지기관효천(간칭효천)환자적비대세포등분비적일충주요적전렬선소류물질.진관타재효천발병궤제중적작용상불완전청초.단대량연구표명PGD2통과상응수체개도삼여효천적형성.최근,대우신형Th2세포상표체적화학추향성수체동충분자(chemoattractant receptor homologous molecule expressed on Th2 cells,CRTH2)수체적연구취득신진전,전렬선소류수체(d prostanoid receptor,DP)여CRTH2량자협동작용유도염증세포천이화세포인자적산생,개도효천등과민성질병적발생발전과정.해편주요종술PGD2급기수체CRTH2재효천발병중작용궤제적최신연구진전.
Prostaglandin D2 (PGD2) is a major prostanoid produced mainly by mast cells in allergic diseases,including bronchial asthma (asthma).However,little was known of the role it plays in the pathophysiology of asthma.Recently,a novel and different receptor of PGD2,CRTH2,has been discovered.To date,DP and CRTH2 have been shown to be major PGD2-related receptors that have pivotal roles in mediating allergic diseases by effects such as directly regulating the migration of inflammatory cells and controlling the production of cytokines and lipid mediators.Available evidence suggests that CRTH2 and DP may collaborate in allergic inflammation.This review focuses on the novel roles of PGD2 and CRTH2 in the pathogenesis of asthma.
