国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
5期
372-375
,共4页
微生物暴露%支气管哮喘%卫生学说%早期免疫刺激假说%益生菌
微生物暴露%支氣管哮喘%衛生學說%早期免疫刺激假說%益生菌
미생물폭로%지기관효천%위생학설%조기면역자격가설%익생균
Microbial exposure%Bronchial asthma%Hygiene hypothesis%Early immune challenge hypothesis%Probiotics
支气管哮喘(简称哮喘)尤其是儿童哮喘的发病率在全球范围有明显升高,而在农场长大的儿童哮喘发病率较低.哮喘发病率的升高与卫生条件改善、家庭规模缩小和微生物暴露尤其是个体早期微生物暴露机会减少有关,其降低了机体接受“免疫训练”的机会,即“卫生学说”,近期有学者建议改为“早期免疫刺激假说”.该文主要介绍早期微生物及微生物组分暴露与哮喘的关系的作用机制进展,早期微生物暴露可能是潜在的预防哮喘的新途径.
支氣管哮喘(簡稱哮喘)尤其是兒童哮喘的髮病率在全毬範圍有明顯升高,而在農場長大的兒童哮喘髮病率較低.哮喘髮病率的升高與衛生條件改善、傢庭規模縮小和微生物暴露尤其是箇體早期微生物暴露機會減少有關,其降低瞭機體接受“免疫訓練”的機會,即“衛生學說”,近期有學者建議改為“早期免疫刺激假說”.該文主要介紹早期微生物及微生物組分暴露與哮喘的關繫的作用機製進展,早期微生物暴露可能是潛在的預防哮喘的新途徑.
지기관효천(간칭효천)우기시인동효천적발병솔재전구범위유명현승고,이재농장장대적인동효천발병솔교저.효천발병솔적승고여위생조건개선、가정규모축소화미생물폭로우기시개체조기미생물폭로궤회감소유관,기강저료궤체접수“면역훈련”적궤회,즉“위생학설”,근기유학자건의개위“조기면역자격가설”.해문주요개소조기미생물급미생물조분폭로여효천적관계적작용궤제진전,조기미생물폭로가능시잠재적예방효천적신도경.
The morbidity of bronchial asthma (asthma),especially childhood asthma,has significantly increased all over the world.However,children who grew up on the farm seemed to be protected from asthma.The growing incidence of asthma was attributed to the improved sanitation,the shrinking family size and the reduced exposure to microbes especially during early childhood,which decreased the chance to accept " Immune training",that's " Hygiene hypothesis",recently a scholar suggested "Early immune challenge hypothesis" instead.This review focuses on recent mechanism studies of the relationship between early microorganisms/microbial components exposure and asthma,early microbial exposure is a new potential avenue to prevent children from asthma.
