CAJ | 학술논문

目的检测Wells评分低、中、高危险度肺血栓栓塞症(PTE)患者血清中同型半胱氨酸的含量,探讨同型半胱氨酸含量与肺栓塞危险度的相关性.方法收集我院收治的PTE患者59例,根据Wells评分规则对其危险度进行分类.其中,低度危险患者19例,中度危险患者27例,高度危险患者13例,以20名健康体检者作为对照.测定血清同型半胱氨酸含量并对其与肺栓塞危险度的相关性进行分析.结果与对照组相比,低、中、高度危险组PTE患者血清同型半胱氨酸的含量均明显升高.并且随着危险度的增高,同型半胱氨酸的含量也升高,两者呈正相关.结论同型半胱氨酸可能是与PTE发病机制有关的重要因素之一.血清同型半胱氨酸的含量不仅可作为PTE发生的预测因子,还可能对发病危险度具有一定的提示作用.
목적 검측Wells평분저、중、고위험도폐혈전전새증(PTE)환자혈청중동형반광안산적함량,탐토동형반광안산함량여폐전새위험도적상관성.방법 수집아원수치적PTE환자59례,근거Wells평분규칙대기위험도진행분류.기중,저도위험환자19례,중도위험환자27례,고도위험환자13례,이20명건강체검자작위대조.측정혈청동형반광안산함량병대기여폐전새위험도적상관성진행분석.결과 여대조조상비,저、중、고도위험조PTE환자혈청동형반광안산적함량균명현승고.병차수착위험도적증고,동형반광안산적함량야승고,량자정정상관.결론 동형반광안산가능시여PTE발병궤제유관적중요인소지일.혈청동형반광안산적함량불부가작위PTE발생적예측인자,환가능대발병위험도구유일정적제시작용.
Objective To detect the serum level of homocysteine in patients with different degrees of pulmonary thromboembolism (PTE) evaluated by Wells method,to explore the correlation between homocysteine level and risk of PTE.Methods 59 patients with PTE in our hospital were collected.The risk degrees of pulmonary embolism were classified by Wells method.Among them,19 patients had low risk,27 patients had moderate risk,and 13 patients had high risk.20 healthy subjects were selected as controls.The serum level of homocysteine was detected and the correlation of it with the risk of pulmonary embolism was analyzed.Results Compared with the control group,the homocysteine levels in low,moderate,high risk group were increased significantly.With the increase of risk,the homocysteine level was also rised.There was a positive correlation.Conclusions Homocysteine may be one of important factors in the pathogenesis of PTE.Serum homocysteine not only can be used as predictors of PTE,but also has a certain implications for the risk degree of pulmonary embolism.