CAJ | 학술논문

蛋白质精氨酸甲基转移酶(protein arginine methyltransferases,PRMTs)是催化S-腺苷-甲硫氨酸的甲基转移至蛋白质精氨酸胍基氮原子上的酶.精氨酸甲基化是一种重要的翻译后修饰方式,参与许多重要的细胞过程,包括DNA修复、RNA加工、转录调控和信号转导.近年来大量研究证实,PRMTs与呼吸系统疾病、心血管系统疾病、肿瘤、病毒感染、糖代谢及其相关疾病、自身免疫性疾病密切相关.明确PRMTs的异常表达对肺部疾病的影响对疾病的治疗有重要作用.
단백질정안산갑기전이매(protein arginine methyltransferases,PRMTs)시최화S-선감-갑류안산적갑기전이지단백질정안산고기담원자상적매.정안산갑기화시일충중요적번역후수식방식,삼여허다중요적세포과정,포괄DNA수복、RNA가공、전록조공화신호전도.근년래대량연구증실,PRMTs여호흡계통질병、심혈관계통질병、종류、병독감염、당대사급기상관질병、자신면역성질병밀절상관.명학PRMTs적이상표체대폐부질병적영향대질병적치료유중요작용.
Protein arginine methyltransferases (PRMTs) are enzymes that catalyze the transfer of a methyl group from S-adenosyl-L-methionine into a guanidino nitrogen of protein arginine.Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events,such as DNA repair,RNA processing,transcriptional regulation,and signal transduction.Recently,many studies reveal that PRMTs are significantly associated with pulmonary diseases,cardiovascular diseases,cancer,infections,glucose metabolic diseases,and autoimmune diseases.The paper introduces the recent progresses in the influence of dysregulation of PRMTs on pulmonary diseases.