国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
11期
805-809
,共5页
王欣妮%叶枫%谢佳星%陈荣昌
王訢妮%葉楓%謝佳星%陳榮昌
왕흔니%협풍%사가성%진영창
慢性阻塞性肺疾病%急性加重%髓系细胞触发受体1%降钙素原
慢性阻塞性肺疾病%急性加重%髓繫細胞觸髮受體1%降鈣素原
만성조새성폐질병%급성가중%수계세포촉발수체1%강개소원
Chronic obstructive pulmonary disease%Acute exacerbation%Triggering receptor expressed on myeloid cell-1%Procalcitionin
目的 探讨髓系细胞触发受体-1(triggering receptor expressed on myeloid cell-1,TREM-1)在慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床应用.方法 随机抽取在我院门诊或住院部诊治的COPD稳定期患者共40例(n=40),按GOLD(肺功能)分级:轻度5例,中度16例,重度13例,极重度6例.全部患者均于稳定期、急性加重期测定TREM-1、降钙素原(PCT),急性加重期行痰细菌培养及痰病毒PCR检查.结果 AECOPD患者TREM-1水平均较稳定期升高,PCT阳性,差异具有统计学意义(P＜0.05).痰细菌培养结果阳性患者TREM-1水平、PCT阳性率较阴性患者均升高,差异具有统计学意义(P＜0.05).痰病毒PCR结果阳性AECOPD患者血清TREM-1水平、PCT阳性率差异无统计学意义.结论 TREM-1在AECOPD中是一个敏感的炎症标志物,可作为早期诊断AECOPD的客观指标.在细菌感染相关的AECOPD患者中TREM-1水平升高,但病毒感染相关者无变化,联合PCT可用于判断细菌感染相关的AECOPD,有利于指导临床抗生素的用药.
目的 探討髓繫細胞觸髮受體-1(triggering receptor expressed on myeloid cell-1,TREM-1)在慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的臨床應用.方法 隨機抽取在我院門診或住院部診治的COPD穩定期患者共40例(n=40),按GOLD(肺功能)分級:輕度5例,中度16例,重度13例,極重度6例.全部患者均于穩定期、急性加重期測定TREM-1、降鈣素原(PCT),急性加重期行痰細菌培養及痰病毒PCR檢查.結果 AECOPD患者TREM-1水平均較穩定期升高,PCT暘性,差異具有統計學意義(P＜0.05).痰細菌培養結果暘性患者TREM-1水平、PCT暘性率較陰性患者均升高,差異具有統計學意義(P＜0.05).痰病毒PCR結果暘性AECOPD患者血清TREM-1水平、PCT暘性率差異無統計學意義.結論 TREM-1在AECOPD中是一箇敏感的炎癥標誌物,可作為早期診斷AECOPD的客觀指標.在細菌感染相關的AECOPD患者中TREM-1水平升高,但病毒感染相關者無變化,聯閤PCT可用于判斷細菌感染相關的AECOPD,有利于指導臨床抗生素的用藥.
목적 탐토수계세포촉발수체-1(triggering receptor expressed on myeloid cell-1,TREM-1)재만성조새성폐질병급성가중기(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)적림상응용.방법 수궤추취재아원문진혹주원부진치적COPD은정기환자공40례(n=40),안GOLD(폐공능)분급:경도5례,중도16례,중도13례,겁중도6례.전부환자균우은정기、급성가중기측정TREM-1、강개소원(PCT),급성가중기행담세균배양급담병독PCR검사.결과 AECOPD환자TREM-1수평균교은정기승고,PCT양성,차이구유통계학의의(P＜0.05).담세균배양결과양성환자TREM-1수평、PCT양성솔교음성환자균승고,차이구유통계학의의(P＜0.05).담병독PCR결과양성AECOPD환자혈청TREM-1수평、PCT양성솔차이무통계학의의.결론 TREM-1재AECOPD중시일개민감적염증표지물,가작위조기진단AECOPD적객관지표.재세균감염상관적AECOPD환자중TREM-1수평승고,단병독감염상관자무변화,연합PCT가용우판단세균감염상관적AECOPD,유리우지도림상항생소적용약.
Objective To investigate the clinical relevance of TREM-1 and PCT in patients with AECOPD.Methods Forty patients with clinically stable COPD were recruited.According to GOLD lung function classification,the severity of COPD was mild in 5 cases,moderate in 16,severe in 13,and extremely severe in 6.The concentrations of TREM-1 and PCT in the serum were measured in all patients both acute exacerbation and stable stage.Pathogen examinations in the sputum culture were measured in all AECOPD patients.Results The levels of TREM-1and PCT were higher in AECOPD patients (P ＜ 0.05).The levels of TREM-1 and PCT was higher in AECOPD patients in whom sputum bacterial culture was positive than those with negative culture (P ＜ 0.05),but not in sputum viral culture positive patients.Conclusions TREM-1 is a sensitive inflammation marker for AECOPD,and may be use as objective index for AECOPD judgement.The level of TREM-1 was higher in AECOPD patients with bacterial infection while not in AECOPD patients with viral infection.The combined determination of serum TREM-1 and PCT may help to direct application of antibiotic.
