国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
11期
827-830
,共4页
低分子肝素%慢性阻塞性肺疾病%临床疗效
低分子肝素%慢性阻塞性肺疾病%臨床療效
저분자간소%만성조새성폐질병%림상료효
Low molecular weight heparin%Chronic obstructive pulmonary disease%Clinical efficacy
目的 探讨早期应用低分子肝素对慢性阻塞性肺疾病急性加重期(AECOPD)临床疗效的影响.方法 根据中华医学会呼吸病学分会慢性阻塞性肺疾病学组制订的COPD诊断标准,纳入哈尔滨医科大学附属第四医院呼吸内科2009年8月-2012年10月明确诊断AECOPD的连续病例140例,随机分为对照组(70例)和抗凝组(70例).对照组患者均采用常规治疗;抗凝组除常规治疗,同时腹部皮下注射低分子肝素,1次/d,10d为一个疗程.所有患者在治疗前后均进行动脉血气分析、D-二聚体、肺功能检测,并统计住院天数.结果 AECOPD患者早期低分子肝素与常规治疗联合应用较常规治疗,明显纠正凝血功能,改善肺功能,纠正低氧和二氧化碳潴留,缩短住院天数.结论 AECOPD早期低分子肝素与常规治疗联合应用可明显提高临床疗效.
目的 探討早期應用低分子肝素對慢性阻塞性肺疾病急性加重期(AECOPD)臨床療效的影響.方法 根據中華醫學會呼吸病學分會慢性阻塞性肺疾病學組製訂的COPD診斷標準,納入哈爾濱醫科大學附屬第四醫院呼吸內科2009年8月-2012年10月明確診斷AECOPD的連續病例140例,隨機分為對照組(70例)和抗凝組(70例).對照組患者均採用常規治療;抗凝組除常規治療,同時腹部皮下註射低分子肝素,1次/d,10d為一箇療程.所有患者在治療前後均進行動脈血氣分析、D-二聚體、肺功能檢測,併統計住院天數.結果 AECOPD患者早期低分子肝素與常規治療聯閤應用較常規治療,明顯糾正凝血功能,改善肺功能,糾正低氧和二氧化碳潴留,縮短住院天數.結論 AECOPD早期低分子肝素與常規治療聯閤應用可明顯提高臨床療效.
목적 탐토조기응용저분자간소대만성조새성폐질병급성가중기(AECOPD)림상료효적영향.방법 근거중화의학회호흡병학분회만성조새성폐질병학조제정적COPD진단표준,납입합이빈의과대학부속제사의원호흡내과2009년8월-2012년10월명학진단AECOPD적련속병례140례,수궤분위대조조(70례)화항응조(70례).대조조환자균채용상규치료;항응조제상규치료,동시복부피하주사저분자간소,1차/d,10d위일개료정.소유환자재치료전후균진행동맥혈기분석、D-이취체、폐공능검측,병통계주원천수.결과 AECOPD환자조기저분자간소여상규치료연합응용교상규치료,명현규정응혈공능,개선폐공능,규정저양화이양화탄저류,축단주원천수.결론 AECOPD조기저분자간소여상규치료연합응용가명현제고림상료효.
Objective To investigate clinical efficacy of intervention with low-molecular-weight-heparin (LMWH) on acute exacerbation of chronic obstructive pulmonary disease.Methods According to COPD diagnostic criteria developed by the Chinese Medical Association Hospital of Harbin Medical University,a total of Fourth Affiliated Hospital of Haerbin Medical University from August 2009 to October 2012.All patients were randomly divided into the control group and the anticoagulation group;meanwhile,the patients of the former group were treated with conventional therapy; In addition to conventional therapy,anticoagulation group received low molecular weight heparin by abdominal subcutaneous injection once every day,with ten days for a course.Before and after treatment,the both groups were detected arterial blood gas analysis,D-dimer,lung function,and to add up hospital day.Results The combination of conventional therapy with low-molecular-weight heparin anticoagulation improved the blood coagulation and pulmonary functions of patients,and corrected hypoxia and carbon dioxide retention,to shorten the hospital day.Conclusions The combination of conventional therapy with low molecular-weight heparin anticoagulation can significantly improve the clinical efficacy in acute exacerbation of chronic obstructive pulmonary disease early.
