国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
11期
831-834
,共4页
阳书坤%霍开秀%陈兰春%张佳宾%徐福琴%丘自挺
暘書坤%霍開秀%陳蘭春%張佳賓%徐福琴%丘自挺
양서곤%곽개수%진란춘%장가빈%서복금%구자정
阻塞性睡眠呼吸暂停%胰岛素抵抗%Chemerin%Apelin
阻塞性睡眠呼吸暫停%胰島素牴抗%Chemerin%Apelin
조새성수면호흡잠정%이도소저항%Chemerin%Apelin
Obstructive sleep apnea syndrome%Insulin resistance%Chemerin%Apelin
目的 探讨男性OSAHS患者血清Chemerin、Apelin水平与胰岛素抵抗的关系.方法 选择OSAHS患者65例和健康对照组28例,分别采用酶联免疫吸附法测定所有研究对象血清Chemerin、Apelin水平,应用稳态模型评估胰岛素抵抗指数(HOMA-IR).结果 与对照组比较,OSAHS患者血清Chemerin、Apelin水平及HOMA-IR均高于对照组(P值均＜0.05).血清Chemerin和Apelin-12水平与AHI呈正相关(r=0.541和0.506,P＜0.01),与LSaO2和MsaO2均呈负相关(r=-0.451,-0.401和-0.428,-0.385,P值均＜0.01).血清Chemerin和Apelin 12水平与HOMA-IR呈正相关(r=0.438和0.375,P＜0.05),血清Chemerin与血清Apelin-12水平两者呈正相关(r值=0.511,P＜0.01).患者HOMA-IR变化与AHI、LSaO2、血清Chemerin和Apelin-12水平呈线性回归关系.结论 OSAHS患者血清Chemerin、Apelin水平与胰岛素密切相关,同时与患者严重程度和低氧相关.
目的 探討男性OSAHS患者血清Chemerin、Apelin水平與胰島素牴抗的關繫.方法 選擇OSAHS患者65例和健康對照組28例,分彆採用酶聯免疫吸附法測定所有研究對象血清Chemerin、Apelin水平,應用穩態模型評估胰島素牴抗指數(HOMA-IR).結果 與對照組比較,OSAHS患者血清Chemerin、Apelin水平及HOMA-IR均高于對照組(P值均＜0.05).血清Chemerin和Apelin-12水平與AHI呈正相關(r=0.541和0.506,P＜0.01),與LSaO2和MsaO2均呈負相關(r=-0.451,-0.401和-0.428,-0.385,P值均＜0.01).血清Chemerin和Apelin 12水平與HOMA-IR呈正相關(r=0.438和0.375,P＜0.05),血清Chemerin與血清Apelin-12水平兩者呈正相關(r值=0.511,P＜0.01).患者HOMA-IR變化與AHI、LSaO2、血清Chemerin和Apelin-12水平呈線性迴歸關繫.結論 OSAHS患者血清Chemerin、Apelin水平與胰島素密切相關,同時與患者嚴重程度和低氧相關.
목적 탐토남성OSAHS환자혈청Chemerin、Apelin수평여이도소저항적관계.방법 선택OSAHS환자65례화건강대조조28례,분별채용매련면역흡부법측정소유연구대상혈청Chemerin、Apelin수평,응용은태모형평고이도소저항지수(HOMA-IR).결과 여대조조비교,OSAHS환자혈청Chemerin、Apelin수평급HOMA-IR균고우대조조(P치균＜0.05).혈청Chemerin화Apelin-12수평여AHI정정상관(r=0.541화0.506,P＜0.01),여LSaO2화MsaO2균정부상관(r=-0.451,-0.401화-0.428,-0.385,P치균＜0.01).혈청Chemerin화Apelin 12수평여HOMA-IR정정상관(r=0.438화0.375,P＜0.05),혈청Chemerin여혈청Apelin-12수평량자정정상관(r치=0.511,P＜0.01).환자HOMA-IR변화여AHI、LSaO2、혈청Chemerin화Apelin-12수평정선성회귀관계.결론 OSAHS환자혈청Chemerin、Apelin수평여이도소밀절상관,동시여환자엄중정도화저양상관.
Objective To analysis the correlation between serum chemerin and apelin levels and insulin resistance in male patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Sixty-five OSAHS patients (OSAHS group) and 28 healthy voluntrers (control group) were recruited in the study.The states of insulin resistance were evaluated by Homeostasis model assessment.Serum chemerin and apelin levels were measured by ELISA method.Results Compared to the control group,the levels of serum chemerin (0.62±0.10) ng/L vs (0.29±0.03) ng/L and apelin (26.37±8.61) μg/L vs (17.69±4.33) μg/L were significantly higher in patients with OSAHS(P ＜0.01).The homeostasis model assessment insulin resistance(HOMA-IR) was higher in OSAHS group (P ＜0.05).The level of serum chemerin and apelin levels were positive correlation to AHI and HOMA IR (r =0.541,0.506 and 0.438,0.375),which were negatively correlated to the lowest SaO2 and MSaO2 (r =-0.451,-0.401 and-0.428,-0.385).all P ＜0.01.The level of serum chemerin and apelin levels was positive correlated (r =0.511,P ＜ 0.01).The HOMA-IR were in multiple linear regression with AHI,LSaO2,serum chemerin and apelin levels.Conclusions The levels of serum chemerin and apelin were increased and insulin resistance existed in OSAHS patients.and they are correlated to AHI and hypoxia during sleep.
