国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
13期
967-969
,共3页
哮喘急性发作%舒利迭%布地奈德%感染%咳嗽
哮喘急性髮作%舒利迭%佈地奈德%感染%咳嗽
효천급성발작%서리질%포지내덕%감염%해수
Acute episoded asthma%Seretide%Budesonide%Infection%Cough
目的 探讨舒利迭联合布地奈德治疗儿童重度支气管哮喘(简称哮喘)急性发作的临床应用价值.方法 将2010年5月-2013年5月间来我院就诊的102例重度哮喘急性发作的患儿随机分为对照组50例及观察组52例,在给予基础治疗的同时,对照组给予雾化吸入舒利迭50/100 μg,3次/d;观察组雾化吸入舒利迭50/100 μg,3次/d和布地奈德400 μg,2次/d;1疗程为3～6 d;用药结束后对疗效进行评价,记录患者咳嗽、呼吸困难、肺部啰音和喘息的消除时间以及FEV1、PEF和FEV1/FVC的变化情况.结果 观察组总有效率明显高于对照组(88.5％ vs 72％),差异有统计学意义(x2=4.38,P＜0.05);两组患者治疗后FEV1、PEF和FEV1/FVC均有上升(P＜0.05),且观察组改善明显优于对照组(P＜0.05);观察组的临床症状消失时间均低于对照组,其中咳嗽、呼吸困难和喘息的消失时间比较差异有统计学意义(P ＜0.05).结论 舒利迭联合布地奈德治疗儿童重度哮喘急性发作快速、有效,可明显缩短患儿的治疗时间,改善肺功能,值得临床推广使用.
目的 探討舒利迭聯閤佈地奈德治療兒童重度支氣管哮喘(簡稱哮喘)急性髮作的臨床應用價值.方法 將2010年5月-2013年5月間來我院就診的102例重度哮喘急性髮作的患兒隨機分為對照組50例及觀察組52例,在給予基礎治療的同時,對照組給予霧化吸入舒利迭50/100 μg,3次/d;觀察組霧化吸入舒利迭50/100 μg,3次/d和佈地奈德400 μg,2次/d;1療程為3～6 d;用藥結束後對療效進行評價,記錄患者咳嗽、呼吸睏難、肺部啰音和喘息的消除時間以及FEV1、PEF和FEV1/FVC的變化情況.結果 觀察組總有效率明顯高于對照組(88.5％ vs 72％),差異有統計學意義(x2=4.38,P＜0.05);兩組患者治療後FEV1、PEF和FEV1/FVC均有上升(P＜0.05),且觀察組改善明顯優于對照組(P＜0.05);觀察組的臨床癥狀消失時間均低于對照組,其中咳嗽、呼吸睏難和喘息的消失時間比較差異有統計學意義(P ＜0.05).結論 舒利迭聯閤佈地奈德治療兒童重度哮喘急性髮作快速、有效,可明顯縮短患兒的治療時間,改善肺功能,值得臨床推廣使用.
목적 탐토서리질연합포지내덕치료인동중도지기관효천(간칭효천)급성발작적림상응용개치.방법 장2010년5월-2013년5월간래아원취진적102례중도효천급성발작적환인수궤분위대조조50례급관찰조52례,재급여기출치료적동시,대조조급여무화흡입서리질50/100 μg,3차/d;관찰조무화흡입서리질50/100 μg,3차/d화포지내덕400 μg,2차/d;1료정위3～6 d;용약결속후대료효진행평개,기록환자해수、호흡곤난、폐부라음화천식적소제시간이급FEV1、PEF화FEV1/FVC적변화정황.결과 관찰조총유효솔명현고우대조조(88.5％ vs 72％),차이유통계학의의(x2=4.38,P＜0.05);량조환자치료후FEV1、PEF화FEV1/FVC균유상승(P＜0.05),차관찰조개선명현우우대조조(P＜0.05);관찰조적림상증상소실시간균저우대조조,기중해수、호흡곤난화천식적소실시간비교차이유통계학의의(P ＜0.05).결론 서리질연합포지내덕치료인동중도효천급성발작쾌속、유효,가명현축단환인적치료시간,개선폐공능,치득림상추엄사용.
Objective To investigate application value of seretide and budesonide on acute severe asthma in children.Methods One hundred and two patients from May 2010 to May 2013 were randomly divided into observation group with 52 cases and control group with 50 cases.The control group was given seretide 50/100 μg,3 times per day by atomization inhalation,the observation group was given seretide 50/100 μg,3 times per day and budesonide 400 μg,2 times per day.Two groups were treated for 3～6 days.To evaluate curative effect after treatment,and record the eliminate time of cough,dyspnea,lung sound and breathing,and change of FEV1,PEF and FEV1/FVC.Results The total effective rate of observation group was higher than control group significantly (88.5％ vs 72％,x2 =4.38,P ＜0.05),FEV1,PEF and FEV1/FVC of two groups are increased significantly (P ＜0.05) after treatment,and improvation of observation group was obviously better than the control group (P ＜ 0.05).The observation group's time of signs disappeared was lower than the control group,and the eliminate time of cough,dyspnea,lung sound,breathing had significant different from the control group (P ＜ 0.05).Conclusions Combined therapeutic efficiency of seretide and budesonide on acute severe asthma in children is quickly and effectively,can remarkably shorten the patient's treatment time,improve lung function,so it is worthy of clinical use.
