国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
13期
1010-1013
,共4页
陈鸣宇%王鹏磊%王希振%魏钦贤%刘宝娟%刘春丽
陳鳴宇%王鵬磊%王希振%魏欽賢%劉寶娟%劉春麗
진명우%왕붕뢰%왕희진%위흠현%류보연%류춘려
咳嗽敏感性%咳嗽激发%肉桂醛
咳嗽敏感性%咳嗽激髮%肉桂醛
해수민감성%해수격발%육계철
Cough reflex sensitivity%Cough provocation test%Cinnamaldehyde
目的 探讨肉桂醛咳嗽激发试验的方法.方法 采用吸气触发的定量吸入,对35名健康志愿者及25例咳嗽患者行肉桂醛咳嗽激发试验.受试者初步吸入雾化浓度倍增(50,100,200,400,800 mmol/L)的肉桂醛溶液,记录测试期间咳嗽次数.诱发产生≥2和≥5次咳嗽的浓度(C2,C5),用比对数值lg C2和lg C5来判断咳嗽反应的敏感性,并测定受试者前、后肺功能.结果 所有受试者中仅1名出现轻微不适,有恶心感.两组受试者咳嗽激发前、后肺通气指标FEV1、FVC、FEV1/FVC,{[(3.35±0.53) L,(3.35±0.52)L],[(2.76±0.82) L,(2.71±0.73)L]},{[(3.72±0.70) L,(3.71±0.71)L],[(3.30±0.78) L,(3.29±0.76)L]},{[(90.6±5.42)％,(90.9±4.92)％],[(83.6±4.45)％,(82.4+5.04)％]},差异无统计学意义(P值均＞0.05).咳嗽敏感性lg C2和lg C5值分别为[2.48±0.43,2.72±0.35].结合本实验实际吸入浓度,估计肉桂醛咳嗽敏感性正常参考值C2≥200 mmol/L,C5≥400 mmol/L.咳嗽敏感性lg C2和lg C5与性别差异有统计学意义(P＜0.05).结论定量吸入肉桂醛咳嗽激发试验,对正常咳嗽敏感性的建立有参考意义.
目的 探討肉桂醛咳嗽激髮試驗的方法.方法 採用吸氣觸髮的定量吸入,對35名健康誌願者及25例咳嗽患者行肉桂醛咳嗽激髮試驗.受試者初步吸入霧化濃度倍增(50,100,200,400,800 mmol/L)的肉桂醛溶液,記錄測試期間咳嗽次數.誘髮產生≥2和≥5次咳嗽的濃度(C2,C5),用比對數值lg C2和lg C5來判斷咳嗽反應的敏感性,併測定受試者前、後肺功能.結果 所有受試者中僅1名齣現輕微不適,有噁心感.兩組受試者咳嗽激髮前、後肺通氣指標FEV1、FVC、FEV1/FVC,{[(3.35±0.53) L,(3.35±0.52)L],[(2.76±0.82) L,(2.71±0.73)L]},{[(3.72±0.70) L,(3.71±0.71)L],[(3.30±0.78) L,(3.29±0.76)L]},{[(90.6±5.42)％,(90.9±4.92)％],[(83.6±4.45)％,(82.4+5.04)％]},差異無統計學意義(P值均＞0.05).咳嗽敏感性lg C2和lg C5值分彆為[2.48±0.43,2.72±0.35].結閤本實驗實際吸入濃度,估計肉桂醛咳嗽敏感性正常參攷值C2≥200 mmol/L,C5≥400 mmol/L.咳嗽敏感性lg C2和lg C5與性彆差異有統計學意義(P＜0.05).結論定量吸入肉桂醛咳嗽激髮試驗,對正常咳嗽敏感性的建立有參攷意義.
목적 탐토육계철해수격발시험적방법.방법 채용흡기촉발적정량흡입,대35명건강지원자급25례해수환자행육계철해수격발시험.수시자초보흡입무화농도배증(50,100,200,400,800 mmol/L)적육계철용액,기록측시기간해수차수.유발산생≥2화≥5차해수적농도(C2,C5),용비대수치lg C2화lg C5래판단해수반응적민감성,병측정수시자전、후폐공능.결과 소유수시자중부1명출현경미불괄,유악심감.량조수시자해수격발전、후폐통기지표FEV1、FVC、FEV1/FVC,{[(3.35±0.53) L,(3.35±0.52)L],[(2.76±0.82) L,(2.71±0.73)L]},{[(3.72±0.70) L,(3.71±0.71)L],[(3.30±0.78) L,(3.29±0.76)L]},{[(90.6±5.42)％,(90.9±4.92)％],[(83.6±4.45)％,(82.4+5.04)％]},차이무통계학의의(P치균＞0.05).해수민감성lg C2화lg C5치분별위[2.48±0.43,2.72±0.35].결합본실험실제흡입농도,고계육계철해수민감성정상삼고치C2≥200 mmol/L,C5≥400 mmol/L.해수민감성lg C2화lg C5여성별차이유통계학의의(P＜0.05).결론정량흡입육계철해수격발시험,대정상해수민감성적건립유삼고의의.
Objective To assess the application of cinnamaldehyde cough provocation test.Methods Cinnamaldehyde inhalation cough challenge test by dosimeter method was performed on 35 health volunteers and 25 cough patients.Each subject inhaled doubling concentrations of cinnamaldehyde (50,100,200,400,800 mmol/L) by a breath-activated dosimeter until the concentration induceing [Inducing] five or more coughs (C5) was reached.The lg C2 and lg C5 were calculated as the cough reflex sensitivity.General lung ventilation was measured before and after the cough provocation test.Results There was no serious side effect of the test in all subjects,only one subject has a sense of nausea.Before and after the test,the provocation the values of FEV1,FVC,FEV1/FVC,{[(3.35 ± 0.53) L,(3.35 ± 0.52) L],[(2.76±0.82) L,(2.71±0.73) L]},{[(3.72±0.70) L,(3.71±0.71) L],[(3.30±0.78) L,(3.29±0.76) L]},{[(90.6±5.42) ％,(90.9±4.92) ％],[(83.6±4.45) ％,(82.4+5.04) ％]},showed no significant(P ＜ 0.05).The lg C2 and lg C5 value is (2.48 ± 0.43) mmol/L,(2.59 ± 0.39) mmol/L.According to our study,we can know the reference value is C2 ≥200 mmol/L,C5 ≥400 mmol/L.However,cough sensitivity is different with gender.Each group all show significant difference (all P ＜0.05).Conclusions Cinnamaldehyde cough provocation test by dosimeter method is of benefit for the development of cough reflex sensitivity.
