国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
13期
1021-1023
,共3页
血管内皮生长因子%微血管密度%气管腺样囊性癌
血管內皮生長因子%微血管密度%氣管腺樣囊性癌
혈관내피생장인자%미혈관밀도%기관선양낭성암
Vascular endothelial growth factor%Microvessel density%Tracheal adenoid cystic carcinoma
目的 了解气管恶性、低度恶性及良性组织中的新生血管有无明显差异.方法 选取煤炭总医院经气管镜下取出的鳞癌、气管腺样囊性癌及炎性肉芽肿蜡块标本各30例.采用SP免疫组织化学法检测血管内皮生长因子(VEGF)和CD34,依据CD34阳性血管计算微血管密度(MVD)值.统计学处理:计量资料均数用方差齐性检验,计数资料用x2检验,组间比较采用Q检验.结果 ①VEGF在气管鳞癌、气管腺样囊性癌和炎性肉芽肿中的表达逐渐降低,组间比较差异有统计学意义(P＜0.05).②气管腺样囊性癌VEGF的表达强弱及MVD值与患者的性别、年龄无关,与临床分期有关,Ⅳ期患者高于其他患者(P＜0.05).结论 新生血管在肿瘤的发生及血行转移中有重要作用.
目的 瞭解氣管噁性、低度噁性及良性組織中的新生血管有無明顯差異.方法 選取煤炭總醫院經氣管鏡下取齣的鱗癌、氣管腺樣囊性癌及炎性肉芽腫蠟塊標本各30例.採用SP免疫組織化學法檢測血管內皮生長因子(VEGF)和CD34,依據CD34暘性血管計算微血管密度(MVD)值.統計學處理:計量資料均數用方差齊性檢驗,計數資料用x2檢驗,組間比較採用Q檢驗.結果 ①VEGF在氣管鱗癌、氣管腺樣囊性癌和炎性肉芽腫中的錶達逐漸降低,組間比較差異有統計學意義(P＜0.05).②氣管腺樣囊性癌VEGF的錶達彊弱及MVD值與患者的性彆、年齡無關,與臨床分期有關,Ⅳ期患者高于其他患者(P＜0.05).結論 新生血管在腫瘤的髮生及血行轉移中有重要作用.
목적 료해기관악성、저도악성급량성조직중적신생혈관유무명현차이.방법 선취매탄총의원경기관경하취출적린암、기관선양낭성암급염성육아종사괴표본각30례.채용SP면역조직화학법검측혈관내피생장인자(VEGF)화CD34,의거CD34양성혈관계산미혈관밀도(MVD)치.통계학처리:계량자료균수용방차제성검험,계수자료용x2검험,조간비교채용Q검험.결과 ①VEGF재기관린암、기관선양낭성암화염성육아종중적표체축점강저,조간비교차이유통계학의의(P＜0.05).②기관선양낭성암VEGF적표체강약급MVD치여환자적성별、년령무관,여림상분기유관,Ⅳ기환자고우기타환자(P＜0.05).결론 신생혈관재종류적발생급혈행전이중유중요작용.
Objective To determine the neovascularization in malignant,low-grade malignant tracheal cancer,and benign tracheal lesions.Methods Thirty specimens of paraffin-embedded bronchoscopic biopsy tissue from patients with adenoid cystic carcinoma,30 of tracheal squamous cancer and 30 of inflammatory granuloma,were collected at Meitan General Hospital during year 2004 to 2013.The detection of vascular endothelial growth factor expression and comparison of microvessel density are detected in all of the specimens.The results were statistically analyzed.Results The VEGF expression and MVD was gradually declined from squamous cell carcinoma to tracheal adenoid cystic carcinoma and inflammatory granuloma,in compliance with the mentioned sequence.The positive expression of VEGF and MVD count has a correlation with clinical stage,while outstanding higher expression observed in stage Ⅳ (P ＜0.05),but not age or gender in adenoid cystic carcinoma.Conclusions Neovascularization plays an important role in tumorigenesis and tumor blood metastasis.
