CAJ | 학술논문

Survivin是凋亡抑制蛋白家族的新成员,也是目前发现的最强的凋亡抑制蛋白.Survivin参与调控细胞周期的两个基本过程,即抑制细胞凋亡和促进细胞增殖.目前研究表明survivin调节肺动脉平滑肌细胞的增殖,在肺动脉高压的肺动脉中膜高表达.通过研究survivin在肺动脉高压发病过程中的作用,可以为肺动脉高压的治疗提供新的思路和手段.
Survivin시조망억제단백가족적신성원,야시목전발현적최강적조망억제단백.Survivin삼여조공세포주기적량개기본과정,즉억제세포조망화촉진세포증식.목전연구표명survivin조절폐동맥평활기세포적증식,재폐동맥고압적폐동맥중막고표체.통과연구survivin재폐동맥고압발병과정중적작용,가이위폐동맥고압적치료제공신적사로화수단.
Survivin is a new member of the inhibitor of apoptosis (IAP) family of proteins,which is also currently the strongest discovered inhibitor of apoptosis protein.Survivin regulates two essential cellular processes,i.e.,it inhibits apoptosis and promotes cell proliferation.Recent studies show that survivin regulates pulmonary artery smooth muscle cell proliferation,which keeps on a high level expression in media of pulmonary artery from pulmonary hypertension.By studying in the role of survivin in the pathogenesis of pulmonary hypertension can provide new ideas and means in therapy of pulmonary hypertension.