CAJ | 학술논문

目的回顾性分析多重耐药(MDR)革兰阴性菌和非MDR革兰阴性菌肺部感染的差异,探讨MDR细菌对患者的影响,给临床医师选择用药提供参考.方法收集我院2012年1月至2012年12月合格呼吸道标本、血液、胸腔积液等临床标本中分离出的MDR革兰阴性菌和非MDR革兰阴性菌,根据临床资料将导致肺部感染的病例纳入研究,分析MDR组和非MDR组之间的差异.结果 MDR革兰阴性菌和非MDR革兰阴性菌科室分布不同.MDR革兰阴性菌和非MDR革兰阴性菌在住院天数、血清白蛋白、日均住院费用、先期使用抗生素、先期使用碳青霉烯类抗生素、病死率之间的差异有统计学意义(P＜0.05),在年龄、血红蛋白、感染时间之间的差异无统计学意义(P＞0.05).结论 MDR革兰阴性菌感染是临床抗生素选择面临的挑战,增加患者病死率,增加住院费用,我们需要高度重视.
목적 회고성분석다중내약(MDR)혁란음성균화비MDR혁란음성균폐부감염적차이,탐토MDR세균대환자적영향,급림상의사선택용약제공삼고.방법 수집아원2012년1월지2012년12월합격호흡도표본、혈액、흉강적액등림상표본중분리출적MDR혁란음성균화비MDR혁란음성균,근거림상자료장도치폐부감염적병례납입연구,분석MDR조화비MDR조지간적차이.결과 MDR혁란음성균화비MDR혁란음성균과실분포불동.MDR혁란음성균화비MDR혁란음성균재주원천수、혈청백단백、일균주원비용、선기사용항생소、선기사용탄청매희류항생소、병사솔지간적차이유통계학의의(P＜0.05),재년령、혈홍단백、감염시간지간적차이무통계학의의(P＞0.05).결론 MDR혁란음성균감염시림상항생소선택면림적도전,증가환자병사솔,증가주원비용,아문수요고도중시.
Objective To retrospectively investigate the differences of lung infection caused by multi-drug resistant (MDR) gram negative bacteria and non-MDR gram negative bacteria,to study the impact of MDR bacteria in patients,and to provide reference for clinicians to choose treatment.Methods The MDR gram-negative bacteria and non-MDR gram-negative bacteria isolated from qualified respiratory specimens,blood,pleural effusion,and other clinical specimens in our hospital from January 2012 to December 2012 were collected.The cases were recruited when they were clinically diagnosed as lung infection.The differences between MDR group and non MDR group were analyzed.Results MDR gramnegative bacteria and non-MDR gram-negative bacteria distributed in different departments.There was statistical significance in hospital stays,serum albumin,the average daily cost of hospitalization,early use of antibiotics,early use of carbapenems,and mortality between MDR gram negative bacteria and non-MDR gram-negative bacteria (P ＜0.05).There was no statistical significance in age,hemoglobin,duration of infection between two groups (P ＞ 0.05).Conclusions MDR gram-negative bacterial infection is a clinical challenge in selection of antibiotic,it increases mortality and hospital costs,we need to pay close attention.