CAJ | 학술논문

目的研究肺结核(PTB)患者血清IL-17A和IL-17F含量并分析其临床意义.方法 ELISA检测47例PTB患者和26名健康志愿者外周血血清IL-17A和IL-17F含量,并分析其相关性.结果 PTB患者血清IL-17A含量显著高于健康志愿者.PTB患者和健康志愿者两组之间血清IL-17F含量无显著性差异.常规化疗药物治疗前PTB患者血清IL-17A含量显著高于治疗后.痰涂结核菌反应阳性PTB患者血清IL-17A和IL-17F含量显著高于阴性PTB患者.PTB患者血清IL-17A含量与患者性别、年龄均无关.血清IL-17F含量与患者治疗情况、患者性别及年龄均无明显相关.Pearson相关性分析显示,血清IL-17A和IL-17F含量之间无显著相关性.结论 IL-17A和IL-17F均在抗结核免疫过程中发挥重要作用.
목적 연구폐결핵(PTB)환자혈청IL-17A화IL-17F함량병분석기림상의의.방법 ELISA검측47례PTB환자화26명건강지원자외주혈혈청IL-17A화IL-17F함량,병분석기상관성.결과 PTB환자혈청IL-17A함량현저고우건강지원자.PTB환자화건강지원자량조지간혈청IL-17F함량무현저성차이.상규화료약물치료전PTB환자혈청IL-17A함량현저고우치료후.담도결핵균반응양성PTB환자혈청IL-17A화IL-17F함량현저고우음성PTB환자.PTB환자혈청IL-17A함량여환자성별、년령균무관.혈청IL-17F함량여환자치료정황、환자성별급년령균무명현상관.Pearson상관성분석현시,혈청IL-17A화IL-17F함량지간무현저상관성.결론 IL-17A화IL-17F균재항결핵면역과정중발휘중요작용.
Objective To study serum IL-17A and IL-17F contents and analyse its clinical significance in pulmonary tuberculosis (PTB) patients.Methods ELISA was used to detect serum IL-17A and IL-17F contents on 47 PTB patients and 26 healthy volunteers (HV).Pearson correlation analysis was used to analyze the correlation of them.Results Serum IL-17A but not IL-17F level of PTB patients was significantly higher than that in HV group (P ＜0.05).And serum IL-17A but not IL-17F level of PTB patients was significantly decreased after treatment.Serum IL-17A and IL-17F levels of sputum smearpositive PTB patients were significantly higher than those in sputum smear-negative PTB patients.There was no significant correlation of serum IL-17A and IL-17F contents with patient gender or age.The correlation analysis showed that there was no correlation between serum IL-17A and IL-17F levels in PTB patients.Conclusions IL-17A and IL-17F may play a more important role in PTB development.