CAJ | 학술논문

烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide-adenine dinucleotide phosphate,NADPH)氧化酶是人体内广泛存在的一种过氧化物酶,其主要功能是参与氧化呼吸链,催化O2还原为O2-,是细胞内介导活性氧簇(reactive oxygen spieces,ROS)生成的主要成分,ROS参与多种细胞内信号转导途径,引发宿主防御、炎症反应、细胞增生和肥大、血管生成等过程.研究表明,NADPH氧化酶通过ROS的产生与ALI、COPD、肺动脉高压、特发性肺纤维化及心血管疾病等的发生发展密切相关.本文就NADPH氧化酶与呼吸系统常见疾病的关系作一综述.
연선알선표령이핵감산린산(nicotinamide-adenine dinucleotide phosphate,NADPH)양화매시인체내엄범존재적일충과양화물매,기주요공능시삼여양화호흡련,최화O2환원위O2-,시세포내개도활성양족(reactive oxygen spieces,ROS)생성적주요성분,ROS삼여다충세포내신호전도도경,인발숙주방어、염증반응、세포증생화비대、혈관생성등과정.연구표명,NADPH양화매통과ROS적산생여ALI、COPD、폐동맥고압、특발성폐섬유화급심혈관질병등적발생발전밀절상관.본문취NADPH양화매여호흡계통상견질병적관계작일종술.
Nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases are a kind of peroxidase in the human body,which is mainly involved in oxidative respiratory chain,catalyzing reduction from O2 to O2,as well as the main component for mediating the generation of intracellular reactive oxygen spieces (ROS).ROS is involved in a variety of intraeellular signal transduction pathways,initiating host defense,inflammation,cell proliferation and hypertrophy,angiogenesis,and other processes.Studies have shown that NADPH oxidases are closely related to the occurrence and development of acute lung injury,chronic obstructive pulmonary disease,pulmonary hypertension,idiopathic pulmonary fibrosis,and cardiovascular diseases through ROS generation.In this paper,relations between NADPH oxidase and common diseases of the respiratory system are reviewed.