CAJ | 학술논문

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者外周血CD3+、CD4+、CD8+及CD16+ 56+细胞的表达变化及胸腺五肽的干预作用.方法用流式细胞术分别检测AECOPD患者21例胸腺五肽干预治疗前、后和健康人对照组20例外周血CD3+、CD4+、CD8+T细胞和CD16+ 56+ (NK)细胞的百分率,比较AECOPD患者与对照组、AECOPD患者胸腺五肽干预前、后淋巴细胞亚群的变化.结果 AECOPD患者与对照组比较,血清CD3+、CD4+、CD16+ 56+百分率、CD4+/CD8+明显降低,差异有统计学意义(P＜0.05);胸腺五肽干预后与干预前比较,血清CD3+、CD4+、CD16+ 56+及CD4+/CD8+比值明显升高,差异有统计学意义(P＜0.05).结论 AECOPD患者机体存在细胞免疫功能紊乱,胸腺五肽干预可提高患者免疫功能.
목적 탐토만성조새성폐질병급성가중기(AECOPD)환자외주혈CD3+、CD4+、CD8+급CD16+ 56+세포적표체변화급흉선오태적간예작용.방법 용류식세포술분별검측AECOPD환자21례흉선오태간예치료전、후화건강인대조조20예외주혈CD3+、CD4+、CD8+T세포화CD16+ 56+ (NK)세포적백분솔,비교AECOPD환자여대조조、AECOPD환자흉선오태간예전、후림파세포아군적변화.결과 AECOPD환자여대조조비교,혈청CD3+、CD4+、CD16+ 56+백분솔、CD4+/CD8+명현강저,차이유통계학의의(P＜0.05);흉선오태간예후여간예전비교,혈청CD3+、CD4+、CD16+ 56+급CD4+/CD8+비치명현승고,차이유통계학의의(P＜0.05).결론 AECOPD환자궤체존재세포면역공능문란,흉선오태간예가제고환자면역공능.
Objective To explore the CD3+,CD4+,CD8+ and CD16+ 56+ cells changes in patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD) and effect of thymopetidum intervention.Methods Flow cytometry was used to detect the changes of CD3+,CD4+,CD8+ T cells and CD16+ 56+ natural killer (NK) cells in peripheral blood of 21 patients at acute severe stage,these patients were treated with thymopetidum and 20 normal controls.Results The levels of serum CD3+,CD4+,CD16+ 56+ levels,CD4+/CD8+ in patients with AECOPD were lower than the control group,the difference was of statistically significant (P ＜ 0.05).After treatment,the CD3+,CD4+,CD16+ 56+,CD4+/CD8+ were increased significantly in patients with AECOPD,they are significantly different (P ＜ 0.05).Conclusions Patients with AECOPD are of cellular immune dysfunction,thymopetidum therapy can enhance the patient's immune function.