CAJ | 학술논문

cAMP直接激活的交换蛋白(Epac)是新近发现的cAMP下游效应分子,其介导的cAMPEpac信号通路是调控气道平滑肌细胞功能的重要机制.近年来,越来越多的研究证实,在支气管哮喘(简称哮喘)的发病过程中,气道平滑肌细胞出现过度收缩、增殖与迁移、合成并分泌炎性介质等病理生理过程均与cAMP-Epac信号通路密切相关.本文就cAMP-Epac信号通路在哮喘气道平滑肌细胞中的功能调控作一综述,以期为深入研究气道平滑肌细胞的信号转导机制,以及在哮喘防治中的作用奠定基础.
cAMP직접격활적교환단백(Epac)시신근발현적cAMP하유효응분자,기개도적cAMPEpac신호통로시조공기도평활기세포공능적중요궤제.근년래,월래월다적연구증실,재지기관효천(간칭효천)적발병과정중,기도평활기세포출현과도수축、증식여천이、합성병분비염성개질등병리생리과정균여cAMP-Epac신호통로밀절상관.본문취cAMP-Epac신호통로재효천기도평활기세포중적공능조공작일종술,이기위심입연구기도평활기세포적신호전도궤제,이급재효천방치중적작용전정기출.
Exchange proteins directly activated by cAMP (Epac) is a new cAMP target.cAMP-Epac signaling pathway plays a key role in the functions of airway smooth muscle cells including hypercontractility,proliferation,migration and the production and secretion of inflammatory mediators,which may modulate the processes of hyper-responsiveness,airway remodeling and chronic airway inflammation.In this review,we will give a summary of the potential role of cAMP-Epac signaling pathway in functional regulation of airway smooth muscle cells.