国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
19期
1508-1511
,共4页
安旭%张蔷%谭进%李璐璐%方云云%陈宝元
安旭%張薔%譚進%李璐璐%方雲雲%陳寶元
안욱%장장%담진%리로로%방운운%진보원
阻塞性睡眠呼吸暂停%认知功能障碍%氧化应激%炎症反应%孤束核
阻塞性睡眠呼吸暫停%認知功能障礙%氧化應激%炎癥反應%孤束覈
조새성수면호흡잠정%인지공능장애%양화응격%염증반응%고속핵
Obstructive sleep apnea%Cognitive dysfunction%Oxidative stress%Inflammatory reaction%Nucleus tractus solitarii
阻塞性睡眠呼吸暂停(OSA)是近年来较为常见的一种疾病,可以引起多系统病变.OSA导致的认知功能障碍也越来越受到重视.低氧血症和睡眠结构紊乱诱导的氧化应激和炎症反应等被认为是OSA患者发生认知功能障碍的主要机制.目前一个新的假说强调,在OSA的患者中孤束核的炎症和结构异常在触发记忆和认知功能障碍亦可能发挥举足轻重的作用.因此,进一步研究OSA导致认知功能障碍的病理机制及与孤束核病变的关系,将为OSA患者并发认知功能障碍的防治提供一新视角.
阻塞性睡眠呼吸暫停(OSA)是近年來較為常見的一種疾病,可以引起多繫統病變.OSA導緻的認知功能障礙也越來越受到重視.低氧血癥和睡眠結構紊亂誘導的氧化應激和炎癥反應等被認為是OSA患者髮生認知功能障礙的主要機製.目前一箇新的假說彊調,在OSA的患者中孤束覈的炎癥和結構異常在觸髮記憶和認知功能障礙亦可能髮揮舉足輕重的作用.因此,進一步研究OSA導緻認知功能障礙的病理機製及與孤束覈病變的關繫,將為OSA患者併髮認知功能障礙的防治提供一新視角.
조새성수면호흡잠정(OSA)시근년래교위상견적일충질병,가이인기다계통병변.OSA도치적인지공능장애야월래월수도중시.저양혈증화수면결구문란유도적양화응격화염증반응등피인위시OSA환자발생인지공능장애적주요궤제.목전일개신적가설강조,재OSA적환자중고속핵적염증화결구이상재촉발기억화인지공능장애역가능발휘거족경중적작용.인차,진일보연구OSA도치인지공능장애적병리궤제급여고속핵병변적관계,장위OSA환자병발인지공능장애적방치제공일신시각.
Obstructive sleep apnea (OSA) is a common disease in recent years,and it can cause multiple system lesions.Cognitive dysfunction caused by OSA are getting more and more attention.Oxidative stress and inflammatory reaction induced by hypoxemia and sleep structure disorder was consider the main mechanism of the OSA patients with cognitive impairment.At present,a new hypothesis emphasizes that the inflammation and structural abnormalities in the nucleus tractus solitarii may play an important role in the trigger memory and cognitive dysfunction in patients with OSA.Therefore,we further summarize the relation between pathological mechanism of cognitive dysfunction caused by OSA and the nucleus tractus solitarii lesions,and it will provide a new perspective for the prevention and treatment of cognitive dysfunction in patients with OSA.