国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2009年
5期
303-305
,共3页
陈青锋%肖萍%冯钧帅%杨彦麟%郭振华
陳青鋒%肖萍%馮鈞帥%楊彥麟%郭振華
진청봉%초평%풍균수%양언린%곽진화
肝炎%乙型%慢性%肝纤维化%阿德福韦酯%丹参
肝炎%乙型%慢性%肝纖維化%阿德福韋酯%丹參
간염%을형%만성%간섬유화%아덕복위지%단삼
Hepatitis B%chronic%Hepatic fibrosis%Adefovir dipivoxil%Salvia miltiorrhiza
目的 探讨阿德福韦酯联合丹参治疗慢性乙型肝炎(CHB)肝纤维化的临床疗效.方法 选择符合标准的CHB患者62例,随机分为阿德福韦酯联合丹参组、丹参组和对照组,所有患者于治疗前和治疗1年后检测肝纤维化相关指标、HBV DNA及其肾功能.结果 阿德福韦酯联合丹参组的肝纤维化指标(透明质酸、层黏蛋白、Ⅳ型胶原和TGF-β1)较单用丹参组和对照组明显降低(P＜0.05).结论 阿德福韦酯联合丹参有明显降低血清肝纤维化指标作用.
目的 探討阿德福韋酯聯閤丹參治療慢性乙型肝炎(CHB)肝纖維化的臨床療效.方法 選擇符閤標準的CHB患者62例,隨機分為阿德福韋酯聯閤丹參組、丹參組和對照組,所有患者于治療前和治療1年後檢測肝纖維化相關指標、HBV DNA及其腎功能.結果 阿德福韋酯聯閤丹參組的肝纖維化指標(透明質痠、層黏蛋白、Ⅳ型膠原和TGF-β1)較單用丹參組和對照組明顯降低(P＜0.05).結論 阿德福韋酯聯閤丹參有明顯降低血清肝纖維化指標作用.
목적 탐토아덕복위지연합단삼치료만성을형간염(CHB)간섬유화적림상료효.방법 선택부합표준적CHB환자62례,수궤분위아덕복위지연합단삼조、단삼조화대조조,소유환자우치료전화치료1년후검측간섬유화상관지표、HBV DNA급기신공능.결과 아덕복위지연합단삼조적간섬유화지표(투명질산、층점단백、Ⅳ형효원화TGF-β1)교단용단삼조화대조조명현강저(P＜0.05).결론 아덕복위지연합단삼유명현강저혈청간섬유화지표작용.
Objective To investigate the clinical efficacy of combination treatment of adefovir dipivoxil(ADV)and salvia miltiorrhiza to the hepatic fibrosis caused by hepatitis B.Methods 62 patients with chronic hepatitis B randomly divided into 3 groups:ADV with salvia miltiorrhiza group,salvia miltiorrhiza group and control group.The indicators correlated hepatic fibrosis,HBV DNA and renal function were detected in all patients with chronic hepatitis B before treatment and after one-year treatment.Results The indicators correlated hepatic(LN,HA,IV-C,TGF-β1)with combination treatment of ADV with salvia miltiorrhiza group was the lowest in those groups after one-year treatment P＜0.05).Conclusions Combination treatment of ADV and salvia miltiorrhiza reduce the indicators correlated hepatic fibrosis obviously.
