国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2012年
5期
323-326
,共4页
流感病毒A型,H1N1亚型%疫苗%抗体水平%微量血凝抑制试验
流感病毒A型,H1N1亞型%疫苗%抗體水平%微量血凝抑製試驗
류감병독A형,H1N1아형%역묘%항체수평%미량혈응억제시험
Influenza A virus,H1N1 subtype%Vaccine%Antibody levels%Hemagglutination inhibition
目的 了解人群甲型H1N1流感(pH1N1)疫苗接种后抗体水平变化规律、持续时间以及疫苗接种的免疫效应.方法 应用微量血凝抑制试验(HI)方法对人群免疫前及免疫后1、2、3、7、14个月进行血清抗体检测.结果 免疫前各组人群的pH1N1流感抗体水平较低,1个月后抗体滴度明显上升,并随着时间的延长逐渐下降.VTH组接种季节性流感疫苗后pH1N1抗体滴度上升不明显,而再接种pH1N1流感疫苗后pH1N1抗体滴度升至1∶93,显著低于同期VH组的抗体水平(1∶245).VHT组接种pH1N1疫苗后pH1N1抗体滴度为1∶272,而再进行接种季节性流感疫苗后pH1N1抗体滴度降至1∶196,低于VH组(1∶259),差异无统计学意义(P＞0.05).结论 pH1N1流感疫苗免疫人群的抗体水平随着时间的延长逐渐下降,抗体减弱或消失时提示应重新进行疫苗接种；提前接种季节性流感疫苗可使pH1N1流感抗体水平下降.
目的 瞭解人群甲型H1N1流感(pH1N1)疫苗接種後抗體水平變化規律、持續時間以及疫苗接種的免疫效應.方法 應用微量血凝抑製試驗(HI)方法對人群免疫前及免疫後1、2、3、7、14箇月進行血清抗體檢測.結果 免疫前各組人群的pH1N1流感抗體水平較低,1箇月後抗體滴度明顯上升,併隨著時間的延長逐漸下降.VTH組接種季節性流感疫苗後pH1N1抗體滴度上升不明顯,而再接種pH1N1流感疫苗後pH1N1抗體滴度升至1∶93,顯著低于同期VH組的抗體水平(1∶245).VHT組接種pH1N1疫苗後pH1N1抗體滴度為1∶272,而再進行接種季節性流感疫苗後pH1N1抗體滴度降至1∶196,低于VH組(1∶259),差異無統計學意義(P＞0.05).結論 pH1N1流感疫苗免疫人群的抗體水平隨著時間的延長逐漸下降,抗體減弱或消失時提示應重新進行疫苗接種；提前接種季節性流感疫苗可使pH1N1流感抗體水平下降.
목적 료해인군갑형H1N1류감(pH1N1)역묘접충후항체수평변화규률、지속시간이급역묘접충적면역효응.방법 응용미량혈응억제시험(HI)방법대인군면역전급면역후1、2、3、7、14개월진행혈청항체검측.결과 면역전각조인군적pH1N1류감항체수평교저,1개월후항체적도명현상승,병수착시간적연장축점하강.VTH조접충계절성류감역묘후pH1N1항체적도상승불명현,이재접충pH1N1류감역묘후pH1N1항체적도승지1∶93,현저저우동기VH조적항체수평(1∶245).VHT조접충pH1N1역묘후pH1N1항체적도위1∶272,이재진행접충계절성류감역묘후pH1N1항체적도강지1∶196,저우VH조(1∶259),차이무통계학의의(P＞0.05).결론 pH1N1류감역묘면역인군적항체수평수착시간적연장축점하강,항체감약혹소실시제시응중신진행역묘접충；제전접충계절성류감역묘가사pH1N1류감항체수평하강.
Objectives To find out the antibody levels of healthy people before and after vaccination with pandemic influenza A H1N1 (pH1N1) vaccines,and to observe the protective effect of pH1N1 vaccines.Methods The serological surveillance was carried out on the antibody levels of pH1N1 by the hemagglutination inhibition (HI) test before and month 1,2,3,4,7and 14 after vaccinations.Results The antibody against pH1N1 were low in 3 groups before the immunization.The antibody titer increased in all the subjects after 1 month.Moreover,the decreasing trends in 3 groups persisted until the last observation.In the VTH group,when 1 month after pH1N1 vaccination,the antibody level against pH1N1 increased to 1 ∶ 93,which were lower than the level of VT group (1 ∶ 245) at the same time point.In the VHT group,the antibody titer against pH1N1 was 1∶272 after pH1N1 vaccination,and 1:196 after the reinoculation,which were lower than VT group (1∶259).There was no significant difference between two groups(P ＞ 0.05).Conclusion The antibody level decreases as the time prolonged.When the antibody decreases or disappeared,it suggested to vaccinate again.It can decrease the pH1N1 antibody level to pre-inoculate the influeaza vaccine.
