国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2012年
5期
339-343
,共5页
肝炎,乙型,慢性%核苷(酸)类似物%病毒变异%耐药
肝炎,乙型,慢性%覈苷(痠)類似物%病毒變異%耐藥
간염,을형,만성%핵감(산)유사물%병독변이%내약
Hepatitis B,chronic%Nucleos(t)ide analogues%Viral mutation%Drug resistance
核苷(酸)类似物已广泛应用于慢性乙型肝炎的临床治疗.随着疗程的延长而发生的由病毒基因变异导致的耐药影响了治疗效果.此文主要就核苷(酸)类似物治疗过程中如何预防和治疗耐药以提高抗病毒治疗效果的优化策略进行了综述.
覈苷(痠)類似物已廣汎應用于慢性乙型肝炎的臨床治療.隨著療程的延長而髮生的由病毒基因變異導緻的耐藥影響瞭治療效果.此文主要就覈苷(痠)類似物治療過程中如何預防和治療耐藥以提高抗病毒治療效果的優化策略進行瞭綜述.
핵감(산)유사물이엄범응용우만성을형간염적림상치료.수착료정적연장이발생적유병독기인변이도치적내약영향료치료효과.차문주요취핵감(산)유사물치료과정중여하예방화치료내약이제고항병독치료효과적우화책략진행료종술.
Nucleos(t) ide analogues are widely used in chronic hepatitic B treatment.With the extension of therapeutic duration,drug resistance due to the gene mutations negatively influences therapeutic efficacy.The optimal strategies about how to prevent and treat the drug resistance in the whole-course treatment with nucleos(t)ides in order to improve the efficacy of antiviral therapy are reviewed in this article.
