CAJ | 학술논문

肝脏病理活检是目前评价肝脏病变的金标准,但由于其有创以及阅片者的差异性,限制了肝活检的临床应用.应用Fibroscan测定患者肝脏瞬时弹性(TE)是新近出现的无创、无痛性诊断肝纤维化的方式,由于其安全、可靠、易操作、可重复性好,目前已被广泛应用于各种慢性肝病的诊断、疗效判断以及随访预测.肝脏弹性测定能准确评价慢性肝炎患者肝脏纤维化程度,且与病毒性应答密切相关；能预测门静脉高压、消化道出血、肝癌等终末期肝病并发症等.本文对Fibroscan的临床应用进展及其意义作了综述.
간장병리활검시목전평개간장병변적금표준,단유우기유창이급열편자적차이성,한제료간활검적림상응용.응용Fibroscan측정환자간장순시탄성(TE)시신근출현적무창、무통성진단간섬유화적방식,유우기안전、가고、역조작、가중복성호,목전이피엄범응용우각충만성간병적진단、료효판단이급수방예측.간장탄성측정능준학평개만성간염환자간장섬유화정도,차여병독성응답밀절상관；능예측문정맥고압、소화도출혈、간암등종말기간병병발증등.본문대Fibroscan적림상응용진전급기의의작료종술.
Liver biopsy is regarded as the gold standard in liver fibrosis assessment.The invasion and variation among the pathologistslimit the application of liver biopsy.However,measurement of transient elastography (TE) by Fibroscan is a new method to assess liver fibrosis,which is non-invasive,painless.The characteristics of safety,reliability,reproducibility and easy-manipulation make Fibroscan widely used in the diagnosis,curative effect evaluation and followup of chronic liver disease.Measurement of TE (also liver stiffness measurement,LSM) is reported to evaluate the degree of liver fibrosis accurately and have a positive correlation with viral response.LSM is also demonstrated to predict the portal hypertension,gastrointestinal bleeding,liver cancer and so on.The clinical application and significance of LSM are reviewed in this article.