国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
1期
8-12
,共5页
陈昭华%徐红星%赵星%朱琴芳%俞钱
陳昭華%徐紅星%趙星%硃琴芳%俞錢
진소화%서홍성%조성%주금방%유전
乳头状瘤病毒感染%妇科病患者%发病率%流式荧光杂交法
乳頭狀瘤病毒感染%婦科病患者%髮病率%流式熒光雜交法
유두상류병독감염%부과병환자%발병솔%류식형광잡교법
Papillomavirus infections%Gynecological patients%Prevalence rate%Flow fluorescent hybridization
目的 了解苏州地区妇科疾病患者中人乳头状瘤病毒(HPV)感染状况和各亚型分布.方法 采集2010-2011年苏州地区2183例患有不同程度宫颈疾病的妇科患者宫颈脱落细胞,应用流式荧光杂交技术检测HPV26种亚型(低危亚型7种、高危亚型19种),分析比较2010年与2011年HPV感染率、各亚型分布及不同年龄段HPV的感染情况.结果 HPV总感染率为40.2％,单一亚型感染率高于多重亚型(27.9％:12.3％,x2=166.73,P＜0.01),低危亚型感染率低于高危亚型(9.8％:23.7％,x2=149.69,P＜0.01).低危型均以HPV6、11亚型感染为主；高危型以HPV16、52、58亚型为主.年龄在50～ 59岁HPV感染率最高(51.4％),30～ 39岁HPV感染率最低(35.2％),各年龄段HPV感染率差别有统计学意义(x2=19.65,P＜0.05)；各年龄段高危亚型的构成比均高于低危亚型及混合型(除大于60岁年龄段外),且随年龄增加低危亚型的感染率呈下降趋势而高危亚型的感染率则增高.结论 苏州地区妇科患者中HPV感染率较高,以单一亚型感染及高危亚型感染为主,常见亚型为HPV16、11、6、52、58.不同年龄段HPV感染率及感染类型构成比均不同,50～ 59岁是HPV感染高发年龄段,HPV的分型检测可为其感染的防治提供科学依据.
目的 瞭解囌州地區婦科疾病患者中人乳頭狀瘤病毒(HPV)感染狀況和各亞型分佈.方法 採集2010-2011年囌州地區2183例患有不同程度宮頸疾病的婦科患者宮頸脫落細胞,應用流式熒光雜交技術檢測HPV26種亞型(低危亞型7種、高危亞型19種),分析比較2010年與2011年HPV感染率、各亞型分佈及不同年齡段HPV的感染情況.結果 HPV總感染率為40.2％,單一亞型感染率高于多重亞型(27.9％:12.3％,x2=166.73,P＜0.01),低危亞型感染率低于高危亞型(9.8％:23.7％,x2=149.69,P＜0.01).低危型均以HPV6、11亞型感染為主；高危型以HPV16、52、58亞型為主.年齡在50～ 59歲HPV感染率最高(51.4％),30～ 39歲HPV感染率最低(35.2％),各年齡段HPV感染率差彆有統計學意義(x2=19.65,P＜0.05)；各年齡段高危亞型的構成比均高于低危亞型及混閤型(除大于60歲年齡段外),且隨年齡增加低危亞型的感染率呈下降趨勢而高危亞型的感染率則增高.結論 囌州地區婦科患者中HPV感染率較高,以單一亞型感染及高危亞型感染為主,常見亞型為HPV16、11、6、52、58.不同年齡段HPV感染率及感染類型構成比均不同,50～ 59歲是HPV感染高髮年齡段,HPV的分型檢測可為其感染的防治提供科學依據.
목적 료해소주지구부과질병환자중인유두상류병독(HPV)감염상황화각아형분포.방법 채집2010-2011년소주지구2183례환유불동정도궁경질병적부과환자궁경탈락세포,응용류식형광잡교기술검측HPV26충아형(저위아형7충、고위아형19충),분석비교2010년여2011년HPV감염솔、각아형분포급불동년령단HPV적감염정황.결과 HPV총감염솔위40.2％,단일아형감염솔고우다중아형(27.9％:12.3％,x2=166.73,P＜0.01),저위아형감염솔저우고위아형(9.8％:23.7％,x2=149.69,P＜0.01).저위형균이HPV6、11아형감염위주；고위형이HPV16、52、58아형위주.년령재50～ 59세HPV감염솔최고(51.4％),30～ 39세HPV감염솔최저(35.2％),각년령단HPV감염솔차별유통계학의의(x2=19.65,P＜0.05)；각년령단고위아형적구성비균고우저위아형급혼합형(제대우60세년령단외),차수년령증가저위아형적감염솔정하강추세이고위아형적감염솔칙증고.결론 소주지구부과환자중HPV감염솔교고,이단일아형감염급고위아형감염위주,상견아형위HPV16、11、6、52、58.불동년령단HPV감염솔급감염류형구성비균불동,50～ 59세시HPV감염고발년령단,HPV적분형검측가위기감염적방치제공과학의거.
Objective To explore the prevalence rate and subtype distribution of human papillomavims (HPV)infection in gynecological patients in Suzhou.Methods The cervical exfoliated cells from 2183 patients with cervical diseases in different degree were collected between 2010 and 2011,and 26 subtypes (including 7 low risk subtypes and 19 high risk subtypes) were detected by flow fluorescence hybridization technique.The prevalence rate and subtypes distribution as well as HPV infection in different ages between 2010 and 2011 were analyzed.Results The overall HPV prevalence rate was 40.2％.The prevalence rate of single infection was higher than that of multiple infection (27.9％:12.3％,x2=166.73,P ＜ 0.01) and prevalence rate of low-risk HPV types was lower than that of high-risk subtypes (9.8 ％:23.7 ％,x2 =149.69,P ＜ 0.01).The major subtypes in low-risk HPV were HPV 6 and 11.The most common high-risk subtypes were HPV 16,52 and 58.The highest HPV prevalence rate was found at the age of 50-59 years (51.4％) and the lowest HPV prevalence rate was found at the age of 30-39 years (35.2％).HPV prevalence rate was associated with age(x2=19.65,P ＜ 0.05).The constituent ratio of high-risk subtypes at every age group (except age of ＞60years group) was higer than low-risk and mixed subtypes.Meanwhile,the low-risk subtype infection rates decreased and the multiple subtype infection rates increased with the age increasing.Conclusions The infection rate ofHPV is high in gynecological patients in Suzhou area.The common infected type is single infection and high-risk subtype.HPV16,11,6,52 and 58 are the most common subtypes.Composition ratio of HPV infection rates and infection types are significantly different in the different age groups,the 50-59 years old group was susceptibles.The subtype analysis of HPV can provide scientific evidence in HPV prevention and treatment.
