国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
1期
24-26
,共3页
关节炎%类风湿%血栓前状态%肿瘤坏死因子%全身炎症反应
關節炎%類風濕%血栓前狀態%腫瘤壞死因子%全身炎癥反應
관절염%류풍습%혈전전상태%종류배사인자%전신염증반응
Arthritis,rheumatoid%Prethrombotic state%Tumor necrosis factor%Systemic inflammatory%Response syndrome
目的 通过检测稳定期类风湿关节炎(RA)患者TNF-α、血小板参数及血管性血友病因子(vwF)、纤维蛋白原(Fg)、D-二聚体(D-D)水平,探讨血栓前状态与全身炎症反应关系.方法 选取RA稳定期患者50例和健康对照组50例,测定两组血清中TNF-α、血管性血友病因子、纤维蛋白原、血小板参数、D-D浓度.结果 RA患者TNF-a水平为(2.85±0.48)μg/L,显著高于正常健康志愿者(t=21.274,P＜0.01)；RA患者vWF、Fg、D-D水平分别为(100.57±41.14)％、(4.60±0.65)g/L和(0.33±0.12) mg/L均高于正常健康志愿者,差异有统计学意义(t =3.568、12.422、9.267,P＜0.01)；RA患者TNF-α水平与血小板计数、血小板平均容积、血小板体积分布宽度、大型血小板比例、vWF、Fg、D-D水平呈正相关(r=0.372、0.668、0.585、0.617、0.434、0.653、0.640,P均＜0.01).结论 稳定期RA患者存在全身炎症反应和血栓前状态,稳定期RA患者的全身炎症反应有助于形成血栓前状态.
目的 通過檢測穩定期類風濕關節炎(RA)患者TNF-α、血小闆參數及血管性血友病因子(vwF)、纖維蛋白原(Fg)、D-二聚體(D-D)水平,探討血栓前狀態與全身炎癥反應關繫.方法 選取RA穩定期患者50例和健康對照組50例,測定兩組血清中TNF-α、血管性血友病因子、纖維蛋白原、血小闆參數、D-D濃度.結果 RA患者TNF-a水平為(2.85±0.48)μg/L,顯著高于正常健康誌願者(t=21.274,P＜0.01)；RA患者vWF、Fg、D-D水平分彆為(100.57±41.14)％、(4.60±0.65)g/L和(0.33±0.12) mg/L均高于正常健康誌願者,差異有統計學意義(t =3.568、12.422、9.267,P＜0.01)；RA患者TNF-α水平與血小闆計數、血小闆平均容積、血小闆體積分佈寬度、大型血小闆比例、vWF、Fg、D-D水平呈正相關(r=0.372、0.668、0.585、0.617、0.434、0.653、0.640,P均＜0.01).結論 穩定期RA患者存在全身炎癥反應和血栓前狀態,穩定期RA患者的全身炎癥反應有助于形成血栓前狀態.
목적 통과검측은정기류풍습관절염(RA)환자TNF-α、혈소판삼수급혈관성혈우병인자(vwF)、섬유단백원(Fg)、D-이취체(D-D)수평,탐토혈전전상태여전신염증반응관계.방법 선취RA은정기환자50례화건강대조조50례,측정량조혈청중TNF-α、혈관성혈우병인자、섬유단백원、혈소판삼수、D-D농도.결과 RA환자TNF-a수평위(2.85±0.48)μg/L,현저고우정상건강지원자(t=21.274,P＜0.01)；RA환자vWF、Fg、D-D수평분별위(100.57±41.14)％、(4.60±0.65)g/L화(0.33±0.12) mg/L균고우정상건강지원자,차이유통계학의의(t =3.568、12.422、9.267,P＜0.01)；RA환자TNF-α수평여혈소판계수、혈소판평균용적、혈소판체적분포관도、대형혈소판비례、vWF、Fg、D-D수평정정상관(r=0.372、0.668、0.585、0.617、0.434、0.653、0.640,P균＜0.01).결론 은정기RA환자존재전신염증반응화혈전전상태,은정기RA환자적전신염증반응유조우형성혈전전상태.
Objective To discuss the relation between prethrombotic state and systemic inflammatory response syndrome by examining the levels of tumor necrosis factor-α (TNF-α),platelet parameters,von willebrand factor(vWF),fibrinogen (Fg) and D-dimer (D-D) in patients with stable rheumatoid arthritis (RA).Methods The levels of TNF-α,platelet parameters,vWF,Fg and D-D were determined in 50 patients with stable RA and 50 healthy persons (control group),respectively.Results The level of TNF-α in RA group was (2.85 ± 0.48) μg/L.There was a significant difference between RA group and control group (t =21.274,P ＜ 0.01).The levels of vWF,Fg and D-D in RA group were (100.57±41.14)％,(4.60±0.65) g/L and (0.33±0.12) mg/L,which were significantly higher than those in control group(t =3.568,12.422,9.267,P ＜ 0.01).In RA group,there were significant positive correlations of TNF-αlevel with platelet count,mean platelet volume,platelet distribution width,platelet-large cell ratio,vWF,Fg and D-D levels(r =0.372,0.668,0.585,0.617,0.434,0.653,0.640,P ＜ 0.01).Conclusions The systemic inflammatory response syndrome with prethrombotic state exists in patients with stable RA,and contributes to the formation of prethrombotic state in stable RA.
