国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
6期
383-386
,共4页
宫颈上皮内瘤样病变%人乳头瘤病毒%派特灵
宮頸上皮內瘤樣病變%人乳頭瘤病毒%派特靈
궁경상피내류양병변%인유두류병독%파특령
Cervical intraepithelial neoplasia%Human papillomavirus%Paiteling
目的 探讨派特灵治疗已婚未育妇女宫颈上皮内瘤变Ⅰ级(CIN Ⅰ级)的疗效.方法 回 顾性分析浙江省诸暨市人民医院妇科就诊的185例病理学诊断为CIN Ⅰ级的已婚未育病例的病例资料,分为治疗组(100例)和对照组(85例).派特灵给药3d停药4d为1个疗程,共4个疗程,患者用药结束后3个月复查宫颈刮片(TCT)及人乳头瘤病毒(HPV).对照组确诊后3个月复查TCT和HPV.分析比较两组预后.结果 入组时,治疗组平均(27.87±3.91)岁,HPV阳性率为88.0％(88/100),对照组平均年龄(28.21±3.12)岁,HPV阳性率为83.5％(71/85),两组比较差异无统计学意义(t=-0.7, x2=0.4,P＞0.05).随访结束时,治疗组CIN总体治愈率为81.0％(81/100),HPV转阴率78.4％ (69/88);对照组CIN总体治愈率28.2％(24/85),HPV转阴率36.6％(26/71).两组相比差异均有统计学意义(x2=52.1、28.5,P＜0.01).治疗组和对照组随访结束时TCT和HPV均阳性的患者比例差异有统计学意义(18.0％:49.4％,x2 =25.8,P＜0.01);两组治愈率差异无统计学意义(11.1％:7.1％,x2=0.3,P＞0.05);治疗组TCT阳性和HPV阴性者中治愈率为94.3％ (50/53),对照组为18.5％(5/27),两组比较差异有统计学意义(x2=50.7,P＜0.01).用药期间,患者无明显不良反应.结论 派特灵治疗能显著改善CINⅠ级患者的预后,但在治疗后TCT及HPV仍阳性的患者中治愈率较低.
目的 探討派特靈治療已婚未育婦女宮頸上皮內瘤變Ⅰ級(CIN Ⅰ級)的療效.方法 迴 顧性分析浙江省諸暨市人民醫院婦科就診的185例病理學診斷為CIN Ⅰ級的已婚未育病例的病例資料,分為治療組(100例)和對照組(85例).派特靈給藥3d停藥4d為1箇療程,共4箇療程,患者用藥結束後3箇月複查宮頸颳片(TCT)及人乳頭瘤病毒(HPV).對照組確診後3箇月複查TCT和HPV.分析比較兩組預後.結果 入組時,治療組平均(27.87±3.91)歲,HPV暘性率為88.0％(88/100),對照組平均年齡(28.21±3.12)歲,HPV暘性率為83.5％(71/85),兩組比較差異無統計學意義(t=-0.7, x2=0.4,P＞0.05).隨訪結束時,治療組CIN總體治愈率為81.0％(81/100),HPV轉陰率78.4％ (69/88);對照組CIN總體治愈率28.2％(24/85),HPV轉陰率36.6％(26/71).兩組相比差異均有統計學意義(x2=52.1、28.5,P＜0.01).治療組和對照組隨訪結束時TCT和HPV均暘性的患者比例差異有統計學意義(18.0％:49.4％,x2 =25.8,P＜0.01);兩組治愈率差異無統計學意義(11.1％:7.1％,x2=0.3,P＞0.05);治療組TCT暘性和HPV陰性者中治愈率為94.3％ (50/53),對照組為18.5％(5/27),兩組比較差異有統計學意義(x2=50.7,P＜0.01).用藥期間,患者無明顯不良反應.結論 派特靈治療能顯著改善CINⅠ級患者的預後,但在治療後TCT及HPV仍暘性的患者中治愈率較低.
목적 탐토파특령치료이혼미육부녀궁경상피내류변Ⅰ급(CIN Ⅰ급)적료효.방법 회 고성분석절강성제기시인민의원부과취진적185례병이학진단위CIN Ⅰ급적이혼미육병례적병례자료,분위치료조(100례)화대조조(85례).파특령급약3d정약4d위1개료정,공4개료정,환자용약결속후3개월복사궁경괄편(TCT)급인유두류병독(HPV).대조조학진후3개월복사TCT화HPV.분석비교량조예후.결과 입조시,치료조평균(27.87±3.91)세,HPV양성솔위88.0％(88/100),대조조평균년령(28.21±3.12)세,HPV양성솔위83.5％(71/85),량조비교차이무통계학의의(t=-0.7, x2=0.4,P＞0.05).수방결속시,치료조CIN총체치유솔위81.0％(81/100),HPV전음솔78.4％ (69/88);대조조CIN총체치유솔28.2％(24/85),HPV전음솔36.6％(26/71).량조상비차이균유통계학의의(x2=52.1、28.5,P＜0.01).치료조화대조조수방결속시TCT화HPV균양성적환자비례차이유통계학의의(18.0％:49.4％,x2 =25.8,P＜0.01);량조치유솔차이무통계학의의(11.1％:7.1％,x2=0.3,P＞0.05);치료조TCT양성화HPV음성자중치유솔위94.3％ (50/53),대조조위18.5％(5/27),량조비교차이유통계학의의(x2=50.7,P＜0.01).용약기간,환자무명현불량반응.결론 파특령치료능현저개선CINⅠ급환자적예후,단재치료후TCT급HPV잉양성적환자중치유솔교저.
Objective To evaluate the efficacy of paiteling for cervical intraepithelial neoplasia grade Ⅰ (CIN Ⅰ) treatment on married non pregnant women.Methods The data of 185 married non pregnant cases whose clinic pathological diagnosis were CIN Ⅰ from Zhuji People's Hospital of Zhejiang were retrospectively analyzed.All the cases were divided into the treatment group (100 cases) and control group (85 cases),according to whether they accept paiteling treatment.The treatment group recived paiteling for 3 days withdrawal 4 days as a course,and a total of 4 courses.All patients get cervical scraping smear (TCT)and human papillomavirus (HPV) test 3 months later.Prognostic results were evaluated.Results Before the treatment,cases in treatment group aged (27.87±3.91) years old,the positive rate of HPV was 88.0％ (88/100); cases in control group were (28.21±3.12) years old,the positive rate of HPV was 83.5％ (71/85).There were no significant difference betweens the two groups (t=-0.7,x2=0.4,P＞0.05).At the end of follow up,the CIN total cure rates of treatment group and control group were 81.0％(81/100) and 28.2％(24/85),and the HPV negative rates in two group were 78.4％(69/88)and 36.6％ (26/71),and there were significant differences (x2=52.1,28.5,P＜0.01).Between the treatment and control group,there were statistically significant differences about the proportion of patients who were positive for HPV and TCT at the end of follow up (18.0％∶49.4％,x2 =25.8,P＜0.01),and no significant difference between the cure rates of two groups (11.1％∶7.1％,x2=0.3,P＞0.05); the cure rates of the patients with TCT-positive and HPV-nega-tive were 94.3％ and 18.5％(x2=50.7,P＜0.01).There were no adverse reactions during drug treatment.Conclu-sions Paiteling can significantly improve the prognosis of patients with CIN Ⅰ,but the cure rate of cases with TCT and HPV both positive after treatment is still low.
