国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
6期
390-392
,共3页
王锦春%丁杰锋%陈将南%谭琼
王錦春%丁傑鋒%陳將南%譚瓊
왕금춘%정걸봉%진장남%담경
肝硬化%重型肝炎%血浆置换
肝硬化%重型肝炎%血漿置換
간경화%중형간염%혈장치환
Liver cirrhosis%Severe hepatitis%Plasma exchange
目的 探讨血浆置换对重型肝炎患者肝功能肝纤维化指标的影响及临床疗效.方法 将绍兴市第六人民医院收治的66例重型肝炎患者随机分为2组:对照组30例,给予常规内科治疗;治疗组36例,在对照组治疗基础上加人工肝血浆置换术;观察两组患者治疗前后肝功能及肝纤维化指标的变化情况.结果 两组治疗后ALT、TBil、层黏连蛋白(LN)及Ⅲ型前胶原(PCⅢ)水平较治疗前明显降低,且差异有统计学意义(P＜0.05).治疗组治疗后ALT、TBil、血氨、LN和PCⅢ水平分别为(76.48±10.85) U/L、(71.81±16.67)μmol/L、(52.13±4.71)mmol/L、(100.53±5.73) μg/L和(107.36±11.30) μg/L,与对照组比较,组间差异均有统计学意义(t=4.569、4.012、2.187、2.021、3.232,P＜0.05).治疗组总有效率与对照组相比差异有统计学意义(83.33％:56.67％,x2==0.535,P＜0.05).结论 血浆置换治疗对重型肝炎患者肝功能及肝纤维化指标均有明显改善作用,并能有效缓解患者的临床症状.
目的 探討血漿置換對重型肝炎患者肝功能肝纖維化指標的影響及臨床療效.方法 將紹興市第六人民醫院收治的66例重型肝炎患者隨機分為2組:對照組30例,給予常規內科治療;治療組36例,在對照組治療基礎上加人工肝血漿置換術;觀察兩組患者治療前後肝功能及肝纖維化指標的變化情況.結果 兩組治療後ALT、TBil、層黏連蛋白(LN)及Ⅲ型前膠原(PCⅢ)水平較治療前明顯降低,且差異有統計學意義(P＜0.05).治療組治療後ALT、TBil、血氨、LN和PCⅢ水平分彆為(76.48±10.85) U/L、(71.81±16.67)μmol/L、(52.13±4.71)mmol/L、(100.53±5.73) μg/L和(107.36±11.30) μg/L,與對照組比較,組間差異均有統計學意義(t=4.569、4.012、2.187、2.021、3.232,P＜0.05).治療組總有效率與對照組相比差異有統計學意義(83.33％:56.67％,x2==0.535,P＜0.05).結論 血漿置換治療對重型肝炎患者肝功能及肝纖維化指標均有明顯改善作用,併能有效緩解患者的臨床癥狀.
목적 탐토혈장치환대중형간염환자간공능간섬유화지표적영향급림상료효.방법 장소흥시제륙인민의원수치적66례중형간염환자수궤분위2조:대조조30례,급여상규내과치료;치료조36례,재대조조치료기출상가인공간혈장치환술;관찰량조환자치료전후간공능급간섬유화지표적변화정황.결과 량조치료후ALT、TBil、층점련단백(LN)급Ⅲ형전효원(PCⅢ)수평교치료전명현강저,차차이유통계학의의(P＜0.05).치료조치료후ALT、TBil、혈안、LN화PCⅢ수평분별위(76.48±10.85) U/L、(71.81±16.67)μmol/L、(52.13±4.71)mmol/L、(100.53±5.73) μg/L화(107.36±11.30) μg/L,여대조조비교,조간차이균유통계학의의(t=4.569、4.012、2.187、2.021、3.232,P＜0.05).치료조총유효솔여대조조상비차이유통계학의의(83.33％:56.67％,x2==0.535,P＜0.05).결론 혈장치환치료대중형간염환자간공능급간섬유화지표균유명현개선작용,병능유효완해환자적림상증상.
Objective To explore the effect and clinical significance of plasma exchange to liver function and fibrosis indexes in severe hepatitis patients.Methods Sixty-six severe hepatitis patients in Sixth People's Hospital of Shaoxing were devided into 2 groups:control group (30 cases) and treatment group (36 cases).The patients in the control group were given routine treatment of internal medicine,besides those the treatment group received the treatment of plasma exchange.The changes between two groups were observed before and after the treatment.Results In two groups,the level of ALT,TBil,laminin (LN) and procollagen type Ⅲ (PC Ⅲ) after treatment were lower than that before treatment,and there were statistically significant difference (P＜0.05).After treatment,the level of ALT,TBil,NH3,LN and PCⅢ in treatment group were (76.48±10.85) U/L,(71.81±16.67) μmol/L,(52.13±4.71) mmol/L,(100.53±5.73) μg/L and (107.36±11.30) μg/L,and were significantly lower than that in control group (t=4.569,4.012,2.187,2.021,3.232,P＜0.05).There was statistically significant difference in the total effective rates between the treatment group and the control group (83.33％:56.67％,x2=0.535,P＜0.05).Conclusions Plasma exchange treatment can significantly improve the liver function and fibrosis indexes in patients with severe hepatitis,and effectively relieve the clinical symptoms of the severve hepatitis patients.
