国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2013年
6期
393-396
,共4页
朱芳%朱以军%王利霞%施红旗%楼善贤
硃芳%硃以軍%王利霞%施紅旂%樓善賢
주방%주이군%왕리하%시홍기%루선현
乳头状瘤病霉%L1壳蛋白%宫颈病变%ROC曲线
乳頭狀瘤病黴%L1殼蛋白%宮頸病變%ROC麯線
유두상류병매%L1각단백%궁경병변%ROC곡선
Human papillomavirus%L1 capsid protein%Cervical lesions%ROC curve
目的 评价人乳头瘤病毒(HPV)L1壳蛋白阴性表达诊断宫颈上皮内瘤变(CINⅡ)及以上宫颈病变的价值.方法 应用诊断性试验的Meta分析思路检索国内外相关文献,以合并的敏感性、特异性、阳性似然比、阴性似然比、比值比和95％可信区间(95％CI),ROC曲线下面积(AUC)和Q值等为合并效应量对HPVL1壳蛋白阴性表达诊断CINⅡ及以上宫颈病变的价值进行拟合ROC曲线分析.结果 纳入研究的12篇文献HPV L1壳蛋白阴性表达诊断CINⅡ及以上宫颈病变的合并敏感性为0.81(95％CI:0.78～0.83)、特异性为0.50(95％CI:0.47～0.53)、阳性似然比为1.75(95％CI:1.41～2.18)、阴性似然比为0.38(95％CI:0.29～0.51)、比值比为4.75 (95％CI:2.92～7.72)、AUC为0.74、Q值为0.68.结论 HPV L1壳蛋白阴性表达用于CINⅡ及以上宫颈病变诊断的准确性中等,敏感性较高,但特异性较低,仅适用于CINⅡ及以上宫颈病变的筛查.
目的 評價人乳頭瘤病毒(HPV)L1殼蛋白陰性錶達診斷宮頸上皮內瘤變(CINⅡ)及以上宮頸病變的價值.方法 應用診斷性試驗的Meta分析思路檢索國內外相關文獻,以閤併的敏感性、特異性、暘性似然比、陰性似然比、比值比和95％可信區間(95％CI),ROC麯線下麵積(AUC)和Q值等為閤併效應量對HPVL1殼蛋白陰性錶達診斷CINⅡ及以上宮頸病變的價值進行擬閤ROC麯線分析.結果 納入研究的12篇文獻HPV L1殼蛋白陰性錶達診斷CINⅡ及以上宮頸病變的閤併敏感性為0.81(95％CI:0.78～0.83)、特異性為0.50(95％CI:0.47～0.53)、暘性似然比為1.75(95％CI:1.41～2.18)、陰性似然比為0.38(95％CI:0.29～0.51)、比值比為4.75 (95％CI:2.92～7.72)、AUC為0.74、Q值為0.68.結論 HPV L1殼蛋白陰性錶達用于CINⅡ及以上宮頸病變診斷的準確性中等,敏感性較高,但特異性較低,僅適用于CINⅡ及以上宮頸病變的篩查.
목적 평개인유두류병독(HPV)L1각단백음성표체진단궁경상피내류변(CINⅡ)급이상궁경병변적개치.방법 응용진단성시험적Meta분석사로검색국내외상관문헌,이합병적민감성、특이성、양성사연비、음성사연비、비치비화95％가신구간(95％CI),ROC곡선하면적(AUC)화Q치등위합병효응량대HPVL1각단백음성표체진단CINⅡ급이상궁경병변적개치진행의합ROC곡선분석.결과 납입연구적12편문헌HPV L1각단백음성표체진단CINⅡ급이상궁경병변적합병민감성위0.81(95％CI:0.78～0.83)、특이성위0.50(95％CI:0.47～0.53)、양성사연비위1.75(95％CI:1.41～2.18)、음성사연비위0.38(95％CI:0.29～0.51)、비치비위4.75 (95％CI:2.92～7.72)、AUC위0.74、Q치위0.68.결론 HPV L1각단백음성표체용우CINⅡ급이상궁경병변진단적준학성중등,민감성교고,단특이성교저,부괄용우CINⅡ급이상궁경병변적사사.
Objective To assess the diagnostic value of negative expression of HPV L1 capsid protein for cervical intraepithelial neoplasia (CIN) Ⅱ and above.Methods According to meta-analysis of diagnostic test method,eligible literatures were searched and fitting ROC curve was performed to assess the diagnostic value of negative expression of HPV L1 capsid protein.The results were expressed as pooled sensitivity,specificity,positive likelihood ratio (+LR),negative likelihood ratio (-LR),diagnostic odds ratio (DOR) and 95％ confidence intervals (95％CI),area under curve (A UC) and Q value.Results There were 12 eligible literatures included in this analysis.Fitting ROC curve analysis showed the pooled sensitivity,specificity,+LR,-LR,DOR,A UC and Q value were 0.81 (95％CI:0.78-0.83),0.50 (95％CI:0.47-0.53),1.75 (95％CI:1.41-2.18),0.38 (95％CI:0.29-0.51),4.75 (95％CI:2.92-7.72),0.74 and 0.68,respectively.Conclusions The accuracy of diagnosis is medium according to HPV L1 capsid protein negative expression for the diagnostic of patients with CIN Ⅱ and above,and the sensitivity is high,but the specificity is low,so HPV L1 capsid protein may useful for the screening of patients with CIN Ⅱ and above.
