CAJ | 학술논문

目的了解水痘疫苗接种在水痘突发疫情中的保护效果.方法收集宁波市某区2010-2012年水痘疫情报告信息,计算接种疫苗与否水痘发病率的比值比(OR),疫苗保护率及疫苗的效果指数.随机抽取未出现疫情的小学生109名,使用ELISA法进行水痘IgG抗体检测,评价疫苗接种的效果.结果该区2010-2012年共发生3起一般水痘突发事件,共报告病例40例(无死亡病例),均为幼托儿童和小学生.疫情发生所在班级学生161人,接种疫苗和未接种疫苗者发病率比较差异有统计学意义(19.42％∶59.09％,x2=16.0],P＜0.01),OR值为0.17(95％CI:0.07～0.43).疫苗总体保护率为67.13％,疫苗效果指数为3.05.未出现疫情的109名学生中,有77人接种过疫苗,但水痘IgG抗体检测显示,仅40.26％(31/77)抗体阳性.结论幼托儿童、小学生接种水痘疫苗可有效降低水痘的发病率,水痘疫苗的质量及实际保护效果需进一步评估.
목적 료해수두역묘접충재수두돌발역정중적보호효과.방법 수집저파시모구2010-2012년수두역정보고신식,계산접충역묘여부수두발병솔적비치비(OR),역묘보호솔급역묘적효과지수.수궤추취미출현역정적소학생109명,사용ELISA법진행수두IgG항체검측,평개역묘접충적효과.결과 해구2010-2012년공발생3기일반수두돌발사건,공보고병례40례(무사망병례),균위유탁인동화소학생.역정발생소재반급학생161인,접충역묘화미접충역묘자발병솔비교차이유통계학의의(19.42％∶59.09％,x2=16.0],P＜0.01),OR치위0.17(95％CI:0.07～0.43).역묘총체보호솔위67.13％,역묘효과지수위3.05.미출현역정적109명학생중,유77인접충과역묘,단수두IgG항체검측현시,부40.26％(31/77)항체양성.결론 유탁인동、소학생접충수두역묘가유효강저수두적발병솔,수두역묘적질량급실제보호효과수진일보평고.
Objective To understand the protective effects of varicella vaccination among the students in varicella emergency.Methods The varicella epidemic reporting information of a certain district of Ningbo from 2010 to 2012 were collected,and the morbidity in children with varicella vaccine inoculation or not were compared,the protective rate and the vaccine efficacy index of vaccines were calculated.The antibody of varicella were detected by EL1SA in 109 students from schools without varicella emergency.Results There were 3 varicella outbreaks involving 40 cases (without death) occurred in primary schools and kindergartens in the District during 2010 to 2012.The incidence rate of vaccinated and unvaccinated children were significant difference (19.42％∶ 59.09％,x2=16.01,P＜0.01),the OR was 0.17 (95％ CI:0.07-0.43).The overall vaccine protection rate was 67.13％,vaccine effectiveness index was 3.05.Seventy-seven of 109 students who didn't infect were vaccinated,but results of ELISA showed that the IgG positive rate was only 40.26％ (31/77).Conclusions The varicella vaccination could protect against varicella effectively among students in kindergardens,primary schools.The quality and the actual effectiveness of varicella vaccine should be evaluated again.