CAJ | 학술논문

由于HBV和HIV具有相似的传播途径,乙型肝炎高流行区有5％～20％的HBV和HIV双重感染者.HAART是治疗艾滋病最重要的措施,而我国目前的HAART方案中均包含有拉米夫定,由于拉米夫定的耐药屏障低,长期使用可能出现YMDD变异.目前国内对单纯HBV感染者的YMDD变异研究很多,但关于HBV和HIV双重感染者YMDD变异的相关研究较少,此文就国外学者在这方面的研究作一综述.
유우HBV화HIV구유상사적전파도경,을형간염고류행구유5％～20％적HBV화HIV쌍중감염자.HAART시치료애자병최중요적조시,이아국목전적HAART방안중균포함유랍미부정,유우랍미부정적내약병장저,장기사용가능출현YMDD변이.목전국내대단순HBV감염자적YMDD변이연구흔다,단관우HBV화HIV쌍중감염자YMDD변이적상관연구교소,차문취국외학자재저방면적연구작일종술.
There are 5％-20％ HBV infected petients co-infected with HIV in high hepatitis B endemic area because both the virus have the similar route of transmission.HAART is the most important measure for treatment of AIDS.In China,all HAART schemes contain lamivudine (3TC).Because 3TC has the low resistance barrier,YMDD mutation may occur during the long-term treatment.There are a lot of researches about YMDD mutation in HBV infection,but there are few researches about YMDD mutation in HBV and HIV co-infection in China at present.The study of foreign scholars in this area are reviewed in this paper.