CAJ | 학술논문

梅毒是由梅毒螺旋体引起的一种性传播疾病,近年来已成为全球公共卫生问题.梅毒螺旋体感染后的免疫应答决定了其临床症状与分期.但由于梅毒螺旋体体外培养困难及缺乏合适的免疫动物模型,对梅毒免疫学和病原学的研究一直受到限制.此文就近年来梅毒免疫学方面的研究进展,以及梅毒合并HIV的免疫学协同作用进行综述.
매독시유매독라선체인기적일충성전파질병,근년래이성위전구공공위생문제.매독라선체감염후적면역응답결정료기림상증상여분기.단유우매독라선체체외배양곤난급결핍합괄적면역동물모형,대매독면역학화병원학적연구일직수도한제.차문취근년래매독면역학방면적연구진전,이급매독합병HIV적면역학협동작용진행종술.
Syphilis is a sexually transmitted disease caused by Treponemapallidum,and it has become a public health problem globally.The symptoms and clinical stages of this disease are determined by the state of human's immune response after Treponema pallidum infected.Due to the inability of bacterial culture in vitro and the lack of suitable immunized animal models,the research on the immunology and etiology of the disease is limited.In this article,the advances on immunology of syphilis and synergistic effect of its co-infection with HIV in recent years are summarized.