国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2013年
1期
61-65
,共5页
廖瑾岚%熊祖应%王青%张悦%侯霜%梁伟%张帆%陈丽%郑磊
廖瑾嵐%熊祖應%王青%張悅%侯霜%樑偉%張帆%陳麗%鄭磊
료근람%웅조응%왕청%장열%후상%량위%장범%진려%정뢰
狼疮肾炎%抗体
狼瘡腎炎%抗體
랑창신염%항체
Lupus Nephritis%Antibodies
目的 探讨抗C1q抗体在评价狼疮性肾炎(LN)疾病总体活动性和肾脏活动性中的作用.方法 选择2008年8月至2011年8月于北京大学深圳医院肾活检病理诊断为LN患者46例.ELISA方法检测血清抗C1q抗体滴度,比较该抗体与LN的活动性评分如SLEDAI评分、m-SLEDAI(modified SLEDAI)评分和肾脏活动性指数(RAS)等相关性.结果 抗Clq抗体滴度与SLEDAI、m-SLEDAI呈正相关.当肾脏活动指数RAS ＞11分时,抗C1q抗体(＞20u/ml)、抗dsDNA抗体(＞100u/ml)、补体C3＜0.8mmol/L)、CRP(＞ 8mg/L)与对应的RAS值进行卡方检验,抗C1q抗体和抗dsDNA抗体差异有统计学意义(P＜0.05),皮尔逊卡方值分别为17.043,8.696,其列联系数分别为0.807、0.633.结论 预测LN疾病整体活动性时,抗C1q抗体优于抗dsDNA抗体、补体C3；它与肾脏活动性指数有较好的对应关系.
目的 探討抗C1q抗體在評價狼瘡性腎炎(LN)疾病總體活動性和腎髒活動性中的作用.方法 選擇2008年8月至2011年8月于北京大學深圳醫院腎活檢病理診斷為LN患者46例.ELISA方法檢測血清抗C1q抗體滴度,比較該抗體與LN的活動性評分如SLEDAI評分、m-SLEDAI(modified SLEDAI)評分和腎髒活動性指數(RAS)等相關性.結果 抗Clq抗體滴度與SLEDAI、m-SLEDAI呈正相關.噹腎髒活動指數RAS ＞11分時,抗C1q抗體(＞20u/ml)、抗dsDNA抗體(＞100u/ml)、補體C3＜0.8mmol/L)、CRP(＞ 8mg/L)與對應的RAS值進行卡方檢驗,抗C1q抗體和抗dsDNA抗體差異有統計學意義(P＜0.05),皮爾遜卡方值分彆為17.043,8.696,其列聯繫數分彆為0.807、0.633.結論 預測LN疾病整體活動性時,抗C1q抗體優于抗dsDNA抗體、補體C3；它與腎髒活動性指數有較好的對應關繫.
목적 탐토항C1q항체재평개랑창성신염(LN)질병총체활동성화신장활동성중적작용.방법 선택2008년8월지2011년8월우북경대학심수의원신활검병리진단위LN환자46례.ELISA방법검측혈청항C1q항체적도,비교해항체여LN적활동성평분여SLEDAI평분、m-SLEDAI(modified SLEDAI)평분화신장활동성지수(RAS)등상관성.결과 항Clq항체적도여SLEDAI、m-SLEDAI정정상관.당신장활동지수RAS ＞11분시,항C1q항체(＞20u/ml)、항dsDNA항체(＞100u/ml)、보체C3＜0.8mmol/L)、CRP(＞ 8mg/L)여대응적RAS치진행잡방검험,항C1q항체화항dsDNA항체차이유통계학의의(P＜0.05),피이손잡방치분별위17.043,8.696,기렬련계수분별위0.807、0.633.결론 예측LN질병정체활동성시,항C1q항체우우항dsDNA항체、보체C3；타여신장활동성지수유교호적대응관계.
Objectives To investigate the role of anti-C1 q antibodies in the evaluation of lupus nephritis activity including systemic activity and renal activity.Methods It was enrolled 46 lupus nephritis patients proved by renal biopsy in Peking University Shenzhen Hospital from August 2008 to August 2011.Serum titer of Anti-C1q antibody was detected by enzyme-linked immunosorbent assay (ELISA) following the manufacturer's instructions.We conducted statistical analysis on Anti-C1q antibody,which has correlation with SELENA-SLE Disease Activity Index and modified SELENA-SLE Disease Activity Index (m-SLEDAI) or Renal Activity Score.Results There was a strong positive correlation between the presence of anti-C1q antibody and SLEDAI and m-SLEDAI.As renal activity score (RAS) ＞ 11 with anti-C1 q antibody ＞ 20ug/ml,anti-dsDNA antibodies ＞ 100u/ml,C3 ＜0.8mmoL/L,CRP ＞ 8mg/L,Pearson chi-square test was accomplished between RAS and above parameters.Statistical significance was only found in anti-C1q antibody and anti-dsDNA antibody with RAS.Pearson chi-square values and Contingency coefficient of anti-C1q antibody and anti-dsDNA antibody were 17.043,0.807and 8.696,0.633,respectively.Conclusions Anti-C1q antibody had more predict value in systemic LN activity than anti-dsDNA antibodies and C3.It was correspondence with renal activity score.
