CAJ | 학술논문

目的研究神经干细胞(Neural Stem Cells,NSCs)移植对于治疗糖尿病引起的神经源性膀胱(diabetic neurogenic bladder,DNB)的实验疗效.方法 SD大鼠腹腔注射链脲佐菌素(Streptozotocin,STZ)制造出糖尿病大鼠神经源性膀胱模型,用胰岛素控制血糖后,将从新生SD大鼠海马组织分离培养出的NSCs,通过股静脉注射、膀胱肌肉注射移植入2组糖尿病SD大鼠神经源性膀胱模型中,通过尿流动力学观察移植后8周各组SD大鼠的排尿情况.结果膀胱肌肉注射NSCs,能更好修复糖尿病大鼠神经源性膀胱的受损神经,改善排尿功能.结论 NSCs移植可作为糖尿病大鼠DNB的一种治疗方法.
목적 연구신경간세포(Neural Stem Cells,NSCs)이식대우치료당뇨병인기적신경원성방광(diabetic neurogenic bladder,DNB)적실험료효.방법 SD대서복강주사련뇨좌균소(Streptozotocin,STZ)제조출당뇨병대서신경원성방광모형,용이도소공제혈당후,장종신생SD대서해마조직분리배양출적NSCs,통과고정맥주사、방광기육주사이식입2조당뇨병SD대서신경원성방광모형중,통과뇨류동역학관찰이식후8주각조SD대서적배뇨정황.결과 방광기육주사NSCs,능경호수복당뇨병대서신경원성방광적수손신경,개선배뇨공능.결론 NSCs이식가작위당뇨병대서DNB적일충치료방법.
Objectives To evaluate the therapeutic effect of Neural Stem Cells (NSCs) implantation for Diabetic Neurogenic Bladder(DNB) caused by Diabetes.Methods The SD rat model of DNB,induced by streptozocin(STZ) intraperitoneal injection,were transplanted via femoral vein or bladder muscles according to their group with cultured NSCs deriving from hippocampus of neonatal SD rat,then followed by urodynamics to evaluate their urinary function of different group after 8 weeks of cells implantation.Results The impaired nerve of DNB rat got better recovery for their improved urinary function as the result of NSCs injection to bladder muscles.Conclusions NSCs transplantation could be the potential therapy for DNB rat.