CAJ | 학술논문

目的提高男性泌尿生殖系Paget's病的诊治水平.方法总结19例男性泌尿生殖系Paget's病患者的临床资料.19例中17例为阴囊Paget's病,2例为膀胱癌膀胱全切术后输尿管皮肤乳头Paget's病.最常见的症状是阴囊处皮肤潮红、红色丘疹及皮肤瘙痒症.病变通常表现为皮肤色素过渡沉着或色素沉着不足,也有的表现为溃疡和黏膜白斑症.结果 19例均选择手术治疗,手术切除范围距皮损处l ～2cm.16例随访者中,术后存活时间为12个月～158个月,目前存活8例.l例于术后13个月复发,仍采用手术治疗,效果良好.8例死亡,其中5例死于非肿瘤疾病,2例合并其他系统恶性肿瘤,1例死因不详.结论 Paget's病早期进行组织活检可以明确诊断,早期Paget's患者必要的手术切除范围是无病灶残留和减少复发的前提并对患者术后生存时间无明显影响.
목적 제고남성비뇨생식계Paget's병적진치수평.방법 총결19례남성비뇨생식계Paget's병환자적림상자료.19례중17례위음낭Paget's병,2례위방광암방광전절술후수뇨관피부유두Paget's병.최상견적증상시음낭처피부조홍、홍색구진급피부소양증.병변통상표현위피부색소과도침착혹색소침착불족,야유적표현위궤양화점막백반증.결과 19례균선택수술치료,수술절제범위거피손처l ～2cm.16례수방자중,술후존활시간위12개월～158개월,목전존활8례.l례우술후13개월복발,잉채용수술치료,효과량호.8례사망,기중5례사우비종류질병,2례합병기타계통악성종류,1례사인불상.결론 Paget's병조기진행조직활검가이명학진단,조기Paget's환자필요적수술절제범위시무병조잔류화감소복발적전제병대환자술후생존시간무명현영향.
Objectives To study the diagnosis and treatment of Paget's disease of the male urinogenital system.Methods Between 1994 and 2012,we treated 19 male patients with Paget's disease,aged 43 ～ 85 years with an average of 66.2 years.17 of 9 cases of are scrotum Paget's disease,2 is urethra skin nipple after radical cystoctomy for bladder transitional cell carcinoma.The most common presenting symptom of Paget' disease is erubescence,papula and pruritis.Lesions occasionally show hyperpigmentation or hypopigmentation,some lesions show ulceration or areas of leukoplakia.Results The local surgical excision,ideally with 1 ～ 2 cm margin of normal skin,were pursued for all patients.16 patients were followed up,who survive 12 ～ 158 months after operation,and 8 survivals.One of them was recurrent 13 months after operation and pursued with a second operation and the outcome is satisfying.8 patients died,5 patients succumbed to nontumorous factor,2 patients with other system tumor,1 patient was dysoemia.Conclusions Early diagnosis and prompt treatment are essential to Paget's disease.Enough intraoperative section may ensure no residual disease and diminished recurrence rate and there was no influence of patient 's survival time post operation with early Paget's disease.