CAJ | 학술논문

目的探讨低通量血液透析(LFHD)与高通量血液透析(HFHD)对维持性血液透析(MHD)患者贫血状态的影响.方法选择2011年5月至2012年11月在新疆自治区人民医院血液净化中心行MHD治疗的慢性肾脏病(CKD)5期患者共50例,随机分为LFHD组和HFHD组各25例,观察两组患者首次透析前和治疗3个月后(透析前)的血红蛋白(Hb)、尿素氮(BUN)、全段甲状旁腺激素(iPTH)、白细胞介素-6(IL-6)、血清C反应蛋白(CRP)及血清β2微球蛋白(β2 MG)的变化并进行分析比较.结果 LFHD组与HFHD组首次透析前各项指标比较无统计学差异(P＞0.05)；LFHD组治疗前后比较对BUN、iPTH、IL-6、的清除无差异(P＞0.05),对CRP、β2 MG清除有差异(P＜0.01),对Hb提升有差异(P＜0.01)；HFHD组治疗前后比较对BUN清除无差异(P＞0.05),对iPTH、IL-6、CRP、β2 MG的清除有差异(P＜0.05),对Hb提升有显著差异(P＜0.01)；LFHD组与HFHD组之间治疗后比较对BUN清除无差异(P＞0.05),对iPTH、IL-6、CRP、β2 MG的清除有差异(P＜0.05),对Hb提升有显著差异(P＜0.01).结论 HFHD能够有效清除中分子毒素和微炎症细胞因子,改善透析患者的贫血状态.
목적 탐토저통량혈액투석(LFHD)여고통량혈액투석(HFHD)대유지성혈액투석(MHD)환자빈혈상태적영향.방법 선택2011년5월지2012년11월재신강자치구인민의원혈액정화중심행MHD치료적만성신장병(CKD)5기환자공50례,수궤분위LFHD조화HFHD조각25례,관찰량조환자수차투석전화치료3개월후(투석전)적혈홍단백(Hb)、뇨소담(BUN)、전단갑상방선격소(iPTH)、백세포개소-6(IL-6)、혈청C반응단백(CRP)급혈청β2미구단백(β2 MG)적변화병진행분석비교.결과 LFHD조여HFHD조수차투석전각항지표비교무통계학차이(P＞0.05)；LFHD조치료전후비교대BUN、iPTH、IL-6、적청제무차이(P＞0.05),대CRP、β2 MG청제유차이(P＜0.01),대Hb제승유차이(P＜0.01)；HFHD조치료전후비교대BUN청제무차이(P＞0.05),대iPTH、IL-6、CRP、β2 MG적청제유차이(P＜0.05),대Hb제승유현저차이(P＜0.01)；LFHD조여HFHD조지간치료후비교대BUN청제무차이(P＞0.05),대iPTH、IL-6、CRP、β2 MG적청제유차이(P＜0.05),대Hb제승유현저차이(P＜0.01).결론 HFHD능구유효청제중분자독소화미염증세포인자,개선투석환자적빈혈상태.
Objectives Discusses low flux hemodialysis (LFHD) with high flux hemodialysis (HFHD)state of anemia in patients with maintenance hemodialysis (MHD) effect.Methods Choice Chronic kidney disease(CKD) stage 5 patients a total of 50 cases in the Xinjiang autonomous region people's hospital of MHD blood purification center,which came from May of 2011 to November of 2012.Were randomly divided into LFHD and HFHD group 25 cases each,Observe for the first time through two groups of patients before and after treatment in 3 months,such as:the hemoglobin(Hb),urea nitrogen(BUN),segment parathyroid hormone(iPTH),interleukin-6 (il-6),c-reactive protein(CRP) and serum beta 2 microglobulin(β2 MG) changes were analyzed and compared.Results LFHD group and HFHD dialysis before comparing the indicators for the first time no statistical difference(P＞ 0.05) ; LFHD group before and after treatment comparison of BUN,iPTH,il-6,no difference (P ＞ 0.05),the CRP,β2 MG removal difference(P ＜0.01),Hb ascend have differences(P ＜0.01);HFHD group is cleared to BUN no difference before and after the treatment(P ＞0.05),to iPTH,il-6,CRP,β2 MG removal difference(P ＜0.05),the Hb ascend there is significant difference(P ＜0.01);LFHD group compared with HFHD group after treatment between the BUN no difference(P ＞0.05),to iPTH,il-6,CRP,β2 MG removal difference(P ＜0.05),for Hb ascend significant differences(P ＜ 0.01).Conclusions HFHD can effectively remove the middle molecular toxins and inflammatory cytokines,to improve the anemia status of dialysis patients.