国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2014年
1期
49-52
,共4页
钱慕周%贾蔚%陈澄%顾进
錢慕週%賈蔚%陳澄%顧進
전모주%가위%진징%고진
肾透析%灌流%骨化三醇%骨质疏松
腎透析%灌流%骨化三醇%骨質疏鬆
신투석%관류%골화삼순%골질소송
Renal Dialysis%Perfusion%Calcutriol%Osteoporosis
目的 探讨血液透析联合血液灌流、骨化三醇、维生素C透析液对维持性血液透析(MHD)患者骨质疏松的疗效.方法 将60例MHD患者按有/无骨质疏松分治疗组(A,30例,血液透析联合血液灌流、骨化三醇、维C透析液)与对照组(B,30例,单纯血液透析).比较两组治疗6个月后患者疗效、副作用及骨密度(BMD)值、胰岛素样生长因子-1(IGF-1)、肿瘤坏死因子-a(TNF-a)、甲状旁腺素(PTH)、血肌酐(Scr)、血钙、血磷等指标变化.结果 A组疗效优于B组(P＜0.05),两组副作用差异无统计学意义(P＞0.05);治疗后A组BMD值、IGF-1水平高于B组,而TNF-a、血磷、PTH水平低于B组(P＜0.05);两组治疗前后Scr、Ca水平差异无统计学意义(P＞0.05).治疗前A组IGF-1与骨密度(BMD)值呈正相关,TNF-a、PTH、P与BMD值呈负相关,B组各指标与BMD值无线性回归关系,治疗后A组各指标与BMD值无线性回归关系.结论 血液透析联合血液灌流、骨化三醇、维C透析液治疗能显著降低血PTH、血磷、TNF-a水平,对MHD患者骨质疏松的治疗安全有效.
目的 探討血液透析聯閤血液灌流、骨化三醇、維生素C透析液對維持性血液透析(MHD)患者骨質疏鬆的療效.方法 將60例MHD患者按有/無骨質疏鬆分治療組(A,30例,血液透析聯閤血液灌流、骨化三醇、維C透析液)與對照組(B,30例,單純血液透析).比較兩組治療6箇月後患者療效、副作用及骨密度(BMD)值、胰島素樣生長因子-1(IGF-1)、腫瘤壞死因子-a(TNF-a)、甲狀徬腺素(PTH)、血肌酐(Scr)、血鈣、血燐等指標變化.結果 A組療效優于B組(P＜0.05),兩組副作用差異無統計學意義(P＞0.05);治療後A組BMD值、IGF-1水平高于B組,而TNF-a、血燐、PTH水平低于B組(P＜0.05);兩組治療前後Scr、Ca水平差異無統計學意義(P＞0.05).治療前A組IGF-1與骨密度(BMD)值呈正相關,TNF-a、PTH、P與BMD值呈負相關,B組各指標與BMD值無線性迴歸關繫,治療後A組各指標與BMD值無線性迴歸關繫.結論 血液透析聯閤血液灌流、骨化三醇、維C透析液治療能顯著降低血PTH、血燐、TNF-a水平,對MHD患者骨質疏鬆的治療安全有效.
목적 탐토혈액투석연합혈액관류、골화삼순、유생소C투석액대유지성혈액투석(MHD)환자골질소송적료효.방법 장60례MHD환자안유/무골질소송분치료조(A,30례,혈액투석연합혈액관류、골화삼순、유C투석액)여대조조(B,30례,단순혈액투석).비교량조치료6개월후환자료효、부작용급골밀도(BMD)치、이도소양생장인자-1(IGF-1)、종류배사인자-a(TNF-a)、갑상방선소(PTH)、혈기항(Scr)、혈개、혈린등지표변화.결과 A조료효우우B조(P＜0.05),량조부작용차이무통계학의의(P＞0.05);치료후A조BMD치、IGF-1수평고우B조,이TNF-a、혈린、PTH수평저우B조(P＜0.05);량조치료전후Scr、Ca수평차이무통계학의의(P＞0.05).치료전A조IGF-1여골밀도(BMD)치정정상관,TNF-a、PTH、P여BMD치정부상관,B조각지표여BMD치무선성회귀관계,치료후A조각지표여BMD치무선성회귀관계.결론 혈액투석연합혈액관류、골화삼순、유C투석액치료능현저강저혈PTH、혈린、TNF-a수평,대MHD환자골질소송적치료안전유효.
Objectives To explore curative effect of osteoporosis of hemodialysis unite hemoperfusion,calcitriol,dislysate of VitC in patient with maintenance hemodialysis.Methods Sixty patient who had been undergoing maintenance hemodialysis were divided into treatment group (A,30,patients who took hemodialysis unite Hemoperfusion,calcitriol,dislysate of VitC) and control group (B,40,patients who took hemodialysis alone) according to whether they had/didnt have osteoporosis.Observed curative effect,side effect and vibration of BMD,IGF-1,TNF-a,PTH,SScr,blood calcium,phosphorus,etc after treatment 6 months.Results The curative effect of group A was better than that of group B (P ＜ 0.05),there was no significant difference of side effects between two groups(P ＞0.05) ; the levels of BMD、IGF-1 of group A were higher than those of group B after treatment ;the levels of BMD、IGF-1 of group A were higher than those of group B after treatment,and the levels of TNF-a、P、PTH of group A were lower than those of group B(P ＜ 0.05 all),there were no significant differences of Scr,Ca levels after treatments between two groups(P ＞0.05 all).before treatment,group A had positive correlation of BMD value,and group B had no linear regression correlation of BMD value,The levels of TNF-a、PTH 、P had negative correlation of BMD value,and IGF-1 had greatest influences on BMD value.after treatment,Indices of group A had no linear regression correlation of BMD value.Conclusions Hemodialysis unite hemoperfusion,calcitriol,dislysate of VitC could reduce the levels of PTH、p、TNF-a,it had safe and valid effect on osteoporosis in patients with maintenance hem dialysis.
