国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2014年
1期
58-60
,共3页
糖尿病肾病%骨化三醇%转化生长因子β1
糖尿病腎病%骨化三醇%轉化生長因子β1
당뇨병신병%골화삼순%전화생장인자β1
Diabetic Nephropathies%Calcitriol%Transtorming Growth Factor beta1
目的 探讨1,25-二羟维生素D3联合厄贝沙坦治疗糖尿病肾病(DN)的疗效.观察1,25-二羟维生素D3对DN患者血清肌酐、TGF-β1、尿蛋白等的影响.方法 选取2型DN患者50例.随机分为2个治疗组:A组25例为厄贝沙坦治疗组,B组25例为1,25-二羟维生素D3联合厄贝沙坦治疗组,记录两组患者治疗前后24h尿蛋白、HbAlc、肌酐、尿素氮、血TGF-β1检测结果.比较两组患者相关参数的差异,同时分析相关参数的相关性.结果 B组患者的24h尿蛋白、肌酐、尿素氮、血TGF-β1、尿NAG显著低于A组(P＜0.05).血TGF-β1和尿NAG、24h尿蛋白呈正相关(P＜0.01).结论 1,25-二羟维生素D3联合厄贝沙坦能显著缓解糖尿病肾病患者尿蛋白、尿NAG,下调血TGF-β1水平,延缓肾功能不全进展.
目的 探討1,25-二羥維生素D3聯閤阨貝沙坦治療糖尿病腎病(DN)的療效.觀察1,25-二羥維生素D3對DN患者血清肌酐、TGF-β1、尿蛋白等的影響.方法 選取2型DN患者50例.隨機分為2箇治療組:A組25例為阨貝沙坦治療組,B組25例為1,25-二羥維生素D3聯閤阨貝沙坦治療組,記錄兩組患者治療前後24h尿蛋白、HbAlc、肌酐、尿素氮、血TGF-β1檢測結果.比較兩組患者相關參數的差異,同時分析相關參數的相關性.結果 B組患者的24h尿蛋白、肌酐、尿素氮、血TGF-β1、尿NAG顯著低于A組(P＜0.05).血TGF-β1和尿NAG、24h尿蛋白呈正相關(P＜0.01).結論 1,25-二羥維生素D3聯閤阨貝沙坦能顯著緩解糖尿病腎病患者尿蛋白、尿NAG,下調血TGF-β1水平,延緩腎功能不全進展.
목적 탐토1,25-이간유생소D3연합액패사탄치료당뇨병신병(DN)적료효.관찰1,25-이간유생소D3대DN환자혈청기항、TGF-β1、뇨단백등적영향.방법 선취2형DN환자50례.수궤분위2개치료조:A조25례위액패사탄치료조,B조25례위1,25-이간유생소D3연합액패사탄치료조,기록량조환자치료전후24h뇨단백、HbAlc、기항、뇨소담、혈TGF-β1검측결과.비교량조환자상관삼수적차이,동시분석상관삼수적상관성.결과 B조환자적24h뇨단백、기항、뇨소담、혈TGF-β1、뇨NAG현저저우A조(P＜0.05).혈TGF-β1화뇨NAG、24h뇨단백정정상관(P＜0.01).결론 1,25-이간유생소D3연합액패사탄능현저완해당뇨병신병환자뇨단백、뇨NAG,하조혈TGF-β1수평,연완신공능불전진전.
Objectives To investigate the 1,25-dihydroxyvitamin D3 and irbesartan treatment of diabetic nephropathy.Observation 1,25-dihydroxyvitamin D3 on serum creatinine in patients with DN,serum TGF-β1,urine protein and other effects.Methods 50 patients with type 2 DN.Randomly divided into two treatment groups:A group of 25 cases of irbesartan treatment group,B group 25 cases of 1,25-dihydroxyvitamin D3 and irbesartan treatment group,the two groups of patients before and after 24h urine protein,HbAlc,creatinine,blood urea nitrogen,serum TGF-β1 test results.Two groups were compared for differences related parameters,while the correlation analysis of relevant parameters.Results Group B patients 24h urine protein,creatinine,blood urea nitrogen,serum TGF-β1,urinary NAG was significantly lower in group A(P ＜ 0.05).Serum TGF-β1 and urine NAG,24h urine protein was positively correlated(P ＜ 0.01).Conclusions 1,25-dihydroxyvitamin D3 and irbesartan can significantly relieve urinary protein in patients with diabetic nephropathy,urinary NAG,lowered blood levels of TGF-β1,delaying progress of renal dysfunction.
