CAJ | 학술논문

目的探讨TRPV5在肾组织中的表达对于含钙肾结石形成的影响.方法选取2012年1月～2012年10月在本院接受微创经皮肾镜取石术的56例肾结石患者(分为含钙结石组30例,非含钙结石组26例)进行研究,并选取同期因其他非肾结石原因接受肾脏切除的20例患者为对照组进行对比研究,三组患者均进行24h尿钙以及肾组织TRPV5免疫组化的检测.结果含钙结石组的24h尿钙为8.59±2.48mmol,高于非含钙结石组(6.14±1.74 mmol;P＜0.05)和对照组(6.29±1.80 mmol;P＜0.05).免疫组化检测含钙结石组肾组织中TRPV5强表达3例、中表达7例、低表达20例;非含钙结石组肾组织中TRPV5强表达16例、中表达7例、低表达3例;对照组肾组织中TRPV5强表达11例、中表达8例、低表达1例,含钙结石组肾组织TRPV5的表达与其他两组比较,均有统计学差异(P＜0.05).结论肾组织中TRPV5表达的减少可能是导致含钙肾结石形成的机制之一.
목적 탐토TRPV5재신조직중적표체대우함개신결석형성적영향.방법 선취2012년1월～2012년10월재본원접수미창경피신경취석술적56례신결석환자(분위함개결석조30례,비함개결석조26례)진행연구,병선취동기인기타비신결석원인접수신장절제적20례환자위대조조진행대비연구,삼조환자균진행24h뇨개이급신조직TRPV5면역조화적검측.결과 함개결석조적24h뇨개위8.59±2.48mmol,고우비함개결석조(6.14±1.74 mmol;P＜0.05)화대조조(6.29±1.80 mmol;P＜0.05).면역조화검측함개결석조신조직중TRPV5강표체3례、중표체7례、저표체20례;비함개결석조신조직중TRPV5강표체16례、중표체7례、저표체3례;대조조신조직중TRPV5강표체11례、중표체8례、저표체1례,함개결석조신조직TRPV5적표체여기타량조비교,균유통계학차이(P＜0.05).결론 신조직중TRPV5표체적감소가능시도치함개신결석형성적궤제지일.
Objectives To study the clinical effcet of TRPV5 in the formation of calcium-contained kidney stones.Methods 56 patients with kidney stones treated by mPCNL between January 2012 and October 2012were enrolled.30 cases were calcium-contained kidney stones while 26 cases were non-calcium-contained kidney stones.Another 20 cases treated by nephrectomy of other reasons were enrolled as control group.The data of 24hour urine calcium and expression of TRPV5 in the kidney were studied in all the cases.Results The data of 24 hour urine calcium of calcium-contained kidney stones group were 8.59 ± 2.48 mmol,which were significant higher than that in other two groups(P ＜ 0.05).And the expression of TRPV5 in the kidney were also significant differences between calcium-contained kidney stones group and other two groups.Conclusions The reduced expression of TRPV5 in the kidney could contribute to the formation of calcium-contained kidney stones.