国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2014年
3期
354-356
,共3页
玄先法%刘永兰%王宁%王玉新%邹和群%李清芹%张以勤%周丽娜
玄先法%劉永蘭%王寧%王玉新%鄒和群%李清芹%張以勤%週麗娜
현선법%류영란%왕저%왕옥신%추화군%리청근%장이근%주려나
肾透析%冠心病%脂蛋白类,LDL
腎透析%冠心病%脂蛋白類,LDL
신투석%관심병%지단백류,LDL
Renal Dislysis%Coronary Disease%Lipoproteins,LDL
目的 探讨维持性血液透析患者血浆氧化低密度脂蛋白(ox-LDL)的水平及其意义.方法 对本院维持性血液透析患者66例及健康志愿者22例,用ELISA法测定血浆ox-LDL水平,用全自动生化仪测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、血肌酐(Scr)与血白蛋白(ALB)值.比较其结果并分析其意义.结果 血液透析组血浆ox-LDL水平(4176.9±2038.6μg/L)明显高于对照组(326.9±173.8μg,/L),其差异有统计学意义(P=0.003).血液透析合并冠心病组血浆ox-LDL水平(5021.3±2873.9μg/L)明显高于非合并冠心病组(3163.7±1430.2μg/L,P=0.018).结论 慢性肾衰竭血液透析患者血浆ox-LDL水平显著高于正常人,而合并冠心病患者血浆ox-LDL水平更高,提示ox-LDL水平升高与肾功能衰竭有一定关系,且可能是合并冠心病的重要危险因素.
目的 探討維持性血液透析患者血漿氧化低密度脂蛋白(ox-LDL)的水平及其意義.方法 對本院維持性血液透析患者66例及健康誌願者22例,用ELISA法測定血漿ox-LDL水平,用全自動生化儀測定血清總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白-膽固醇(HDL-C)、低密度脂蛋白-膽固醇(LDL-C)、血肌酐(Scr)與血白蛋白(ALB)值.比較其結果併分析其意義.結果 血液透析組血漿ox-LDL水平(4176.9±2038.6μg/L)明顯高于對照組(326.9±173.8μg,/L),其差異有統計學意義(P=0.003).血液透析閤併冠心病組血漿ox-LDL水平(5021.3±2873.9μg/L)明顯高于非閤併冠心病組(3163.7±1430.2μg/L,P=0.018).結論 慢性腎衰竭血液透析患者血漿ox-LDL水平顯著高于正常人,而閤併冠心病患者血漿ox-LDL水平更高,提示ox-LDL水平升高與腎功能衰竭有一定關繫,且可能是閤併冠心病的重要危險因素.
목적 탐토유지성혈액투석환자혈장양화저밀도지단백(ox-LDL)적수평급기의의.방법 대본원유지성혈액투석환자66례급건강지원자22례,용ELISA법측정혈장ox-LDL수평,용전자동생화의측정혈청총담고순(TC)、감유삼지(TG)、고밀도지단백-담고순(HDL-C)、저밀도지단백-담고순(LDL-C)、혈기항(Scr)여혈백단백(ALB)치.비교기결과병분석기의의.결과 혈액투석조혈장ox-LDL수평(4176.9±2038.6μg/L)명현고우대조조(326.9±173.8μg,/L),기차이유통계학의의(P=0.003).혈액투석합병관심병조혈장ox-LDL수평(5021.3±2873.9μg/L)명현고우비합병관심병조(3163.7±1430.2μg/L,P=0.018).결론 만성신쇠갈혈액투석환자혈장ox-LDL수평현저고우정상인,이합병관심병환자혈장ox-LDL수평경고,제시ox-LDL수평승고여신공능쇠갈유일정관계,차가능시합병관심병적중요위험인소.
Objectives To explore the plasma level and role of oxidized low density lipoprotein (ox-LDL) in maintenance hemodialysis patients.Methods Plasma ox-LDL was measured by sandwich ELISA and the serum total cholesterol,triglyceride,high density lipoprotein-cholesterol,low density lipoprotein-cholesterol,serum creatinine,blood albumin of 66 hemodialysis patients in our hospital were determined and compared with those of 22 healthy controls.Results The plasma levels of ox-LDL was obviously elevated in hemodialysis patients (4176.9μg/L ±2038.6μg/L) compared with control subjects(326.9μg/L ± 173.8μg/L),the differences had statistical significance(P =0.003).And it was higher in hemodialysis patients with coronary heart disease (5021.3μg/L ±2873.9μg/L) than that in hemodialysis patients without coronary heart disease (3163.7μg/L ± 1430.2μg/L) (P =0.018).Conclusions Ox-LDL level in maintenance hemodialysis patients was higher than control subjects and it was even higher in hemodialysis patients with coronary heart disease.It indicated that the increase of ox-LDL may be concerned with renal failure and an important risk factor of coronary heart disease.
