国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2014年
4期
505-508
,共4页
张培新%艾尼娃%李鸣%贾宏亮%蒲春林
張培新%艾尼娃%李鳴%賈宏亮%蒲春林
장배신%애니왜%리명%가굉량%포춘림
前列腺肿瘤%肿瘤转移
前列腺腫瘤%腫瘤轉移
전렬선종류%종류전이
Prostatic Neoplasms%Neoplasm Metastasis
目的 探讨前列腺癌组织中P504S/AMACR表达和Gleason评分与骨转移的相关性.方法 选取2012年7月至2013年6月之间本院收治的前列腺癌58例,其中骨转移患者32例;无骨转移患者26例.采用EnVision免疫组化二步法检测前列腺癌组织中P504S/AMACR的表达,同时分析P504S/AMACR表达和Gleason评分与骨转移的关系.结果 骨转移与P504S/AMACR相关系数为0.818(说明正相关,关系较密切,P ＜0.05);骨转移和Gleason做相关性分析,相关系数为0.474(说明正相关,P＜0.007).经秩和检验分析得骨转移组和无骨转移组的P504S/AMACR表达差异有统计学意义(Z=-4.110,P＜0.001),经秩和检验分析得骨转移组和无骨转移组的Gleason评分差异有统计学意义(Z=-3.372,P=0.001).结论 前列腺癌骨转移患者的组织中P504S/AMACR表达增高,可能为预测前列腺癌骨转移诊断以及预后判断提供更多的依据.
目的 探討前列腺癌組織中P504S/AMACR錶達和Gleason評分與骨轉移的相關性.方法 選取2012年7月至2013年6月之間本院收治的前列腺癌58例,其中骨轉移患者32例;無骨轉移患者26例.採用EnVision免疫組化二步法檢測前列腺癌組織中P504S/AMACR的錶達,同時分析P504S/AMACR錶達和Gleason評分與骨轉移的關繫.結果 骨轉移與P504S/AMACR相關繫數為0.818(說明正相關,關繫較密切,P ＜0.05);骨轉移和Gleason做相關性分析,相關繫數為0.474(說明正相關,P＜0.007).經秩和檢驗分析得骨轉移組和無骨轉移組的P504S/AMACR錶達差異有統計學意義(Z=-4.110,P＜0.001),經秩和檢驗分析得骨轉移組和無骨轉移組的Gleason評分差異有統計學意義(Z=-3.372,P=0.001).結論 前列腺癌骨轉移患者的組織中P504S/AMACR錶達增高,可能為預測前列腺癌骨轉移診斷以及預後判斷提供更多的依據.
목적 탐토전렬선암조직중P504S/AMACR표체화Gleason평분여골전이적상관성.방법 선취2012년7월지2013년6월지간본원수치적전렬선암58례,기중골전이환자32례;무골전이환자26례.채용EnVision면역조화이보법검측전렬선암조직중P504S/AMACR적표체,동시분석P504S/AMACR표체화Gleason평분여골전이적관계.결과 골전이여P504S/AMACR상관계수위0.818(설명정상관,관계교밀절,P ＜0.05);골전이화Gleason주상관성분석,상관계수위0.474(설명정상관,P＜0.007).경질화검험분석득골전이조화무골전이조적P504S/AMACR표체차이유통계학의의(Z=-4.110,P＜0.001),경질화검험분석득골전이조화무골전이조적Gleason평분차이유통계학의의(Z=-3.372,P=0.001).결론 전렬선암골전이환자적조직중P504S/AMACR표체증고,가능위예측전렬선암골전이진단이급예후판단제공경다적의거.
Objectives To investigate the correlation between bone metastases in patients with prostate cancer and P504S expression,Gleason score.Methods From July 2012 to June 2013,58 patients with prostate cancer were collected in our hospital,in which 32 with bone metastasis and 26 without bone metastasis.P504S expression in tissue of prostate cancer were measured using immunohistochemical two-steping of EnVision,All of patients underwent whole body radionuclide bone scan.The role of P504S and Gleason score in bone metastasis were analyzed.Results For prostate cancer with bone metastasis,P504S expression was strength,correlation coefficients were 0.818,there are statistically significant differences (P ＜0.05) ; correlation coefficient with the Gleason scores was 0.474,P ＜ 0.007.By rank and inspection analysis in groups and no bone metastases of bone metastases,P504S expression difference was statistically significant (Z =4.110,P ＜ 0.001),the rank and inspection analysis of bone metastases group and no group of bone metastases of Gleason score,difference was statistically significant (Z =3.372,P =3.372).Conclusions High expression of P504S in prostate cancer patients might be used as a biomarker for bone metastasis in patient with prostate cancer as well as a sensitive indicator of prognosis.
