国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2014年
5期
646-650
,共5页
性腺功能减退症%受体,雄激素%睾酮%大鼠
性腺功能減退癥%受體,雄激素%睪酮%大鼠
성선공능감퇴증%수체,웅격소%고동%대서
Hypogonadism%Receptors,Androgen%Testosterone%Rats
目的 通过观察选择性雄激素受体调节剂对迟发性腺功能减退大鼠的作用,为治疗LOH提供理论依据.方法 将30只符合标准的老年Wistar大鼠作为LOH动物模型,并随机分成3组:对照组(A)、DHT组(B)、Sarm组(C),分别给予空白溶剂、雄激素及选择性雄激素受体调节剂(Sarm)进行干预,实验4周后观察各组大鼠LOH症状的改善情况并评分,检测血清游离睾酮的水平,计算前列腺相关指数.结果 干预4周后A、B、C三组大鼠LOH症状评分分别为(18.20±1.87)、(30.00±2.49)、(35.20±1.87),血清游离睾酮分别为(2.248±0.305)、(1.088±0.258)、(2.526±0.283) pg/mL,前列腺指数分别为(0.321±0.008)％、(0.419±o.015)％、(0.304±0.007)％,各组间差异有统计学意义(P＜0.01).结论 Sarm可能通过其与雄激素受体高度亲和力及选择性调节雄激素受体表达,明显改善LOH模型大鼠的LOH症状,有效抑制前列腺组织的增生,不影响自身睾酮的分泌.
目的 通過觀察選擇性雄激素受體調節劑對遲髮性腺功能減退大鼠的作用,為治療LOH提供理論依據.方法 將30隻符閤標準的老年Wistar大鼠作為LOH動物模型,併隨機分成3組:對照組(A)、DHT組(B)、Sarm組(C),分彆給予空白溶劑、雄激素及選擇性雄激素受體調節劑(Sarm)進行榦預,實驗4週後觀察各組大鼠LOH癥狀的改善情況併評分,檢測血清遊離睪酮的水平,計算前列腺相關指數.結果 榦預4週後A、B、C三組大鼠LOH癥狀評分分彆為(18.20±1.87)、(30.00±2.49)、(35.20±1.87),血清遊離睪酮分彆為(2.248±0.305)、(1.088±0.258)、(2.526±0.283) pg/mL,前列腺指數分彆為(0.321±0.008)％、(0.419±o.015)％、(0.304±0.007)％,各組間差異有統計學意義(P＜0.01).結論 Sarm可能通過其與雄激素受體高度親和力及選擇性調節雄激素受體錶達,明顯改善LOH模型大鼠的LOH癥狀,有效抑製前列腺組織的增生,不影響自身睪酮的分泌.
목적 통과관찰선택성웅격소수체조절제대지발성선공능감퇴대서적작용,위치료LOH제공이론의거.방법 장30지부합표준적노년Wistar대서작위LOH동물모형,병수궤분성3조:대조조(A)、DHT조(B)、Sarm조(C),분별급여공백용제、웅격소급선택성웅격소수체조절제(Sarm)진행간예,실험4주후관찰각조대서LOH증상적개선정황병평분,검측혈청유리고동적수평,계산전렬선상관지수.결과 간예4주후A、B、C삼조대서LOH증상평분분별위(18.20±1.87)、(30.00±2.49)、(35.20±1.87),혈청유리고동분별위(2.248±0.305)、(1.088±0.258)、(2.526±0.283) pg/mL,전렬선지수분별위(0.321±0.008)％、(0.419±o.015)％、(0.304±0.007)％,각조간차이유통계학의의(P＜0.01).결론 Sarm가능통과기여웅격소수체고도친화력급선택성조절웅격소수체표체,명현개선LOH모형대서적LOH증상,유효억제전렬선조직적증생,불영향자신고동적분비.
Objectives To investigate the large effective ways and means for aged male rats of late-onset hypogonadism by selectively modulate androgen receptor.Methods A total of 30 aged male rats were selected as LOH model and randomly divided into 3 groups:control group(A),DHTgroup(B),Sarm group(C).Each group were treated with subcutaneous injection of blank solvent,dihydrotestostemne (DHT)and Sarm during the next 4 weeks.After 4 weeks,we observed and scored the LOH symptoms of every rats,detect the levels of serum free testosterone,and calculate the prostatic index.Results The scores of LOH symptom were 18.20 ± 1.87,30.00 ± 2.49,35.20 ± 1.87,and serum free testosterone were 2.248 ± 0.305,1.088 ± 0.258,2.526 ± 0.283pg/mL,and prostate index were 0.321 ± 0.008,0.419 ± 0.015,0.304 ± 0.007％,the difference between every two groups was statistically significant(P ＜ 0.01).Conclusions By its high affinity and selectivity to adjust androgen receptor expression,Sarm can obviously improve the symptoms of LOH model rat and restrain the hyperplasia of prostate tissue,however,it does not affect the secretion of testosterone.
