国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
6期
416-421
,共6页
白细胞介素17%信号转导%炎症%自身免疫
白細胞介素17%信號轉導%炎癥%自身免疫
백세포개소17%신호전도%염증%자신면역
Interkeukin-17%Signal transduction%Inflammation%Autoimmune
IL-17家族包括IL-17A-IL17F 6个成员,其中IL-17A是其原型.作为一种重要的炎症因子,IL-17可诱导多种与炎症相关的趋化因子、炎性细胞因子及抗菌蛋白的产生,在机体的宿主防御中发挥重要作用.然而,大量的研究证实IL-17与多种自身免疫病及炎症疾病密切相关.鉴于IL-17的宿主防御和免疫损伤的双重作用,人们对IL-17/IL-17R信号转导机制及其生理和病理功能进行了更深入的研究,从而为相关疾病的干预和治疗提供了新的思路.
IL-17傢族包括IL-17A-IL17F 6箇成員,其中IL-17A是其原型.作為一種重要的炎癥因子,IL-17可誘導多種與炎癥相關的趨化因子、炎性細胞因子及抗菌蛋白的產生,在機體的宿主防禦中髮揮重要作用.然而,大量的研究證實IL-17與多種自身免疫病及炎癥疾病密切相關.鑒于IL-17的宿主防禦和免疫損傷的雙重作用,人們對IL-17/IL-17R信號轉導機製及其生理和病理功能進行瞭更深入的研究,從而為相關疾病的榦預和治療提供瞭新的思路.
IL-17가족포괄IL-17A-IL17F 6개성원,기중IL-17A시기원형.작위일충중요적염증인자,IL-17가유도다충여염증상관적추화인자、염성세포인자급항균단백적산생,재궤체적숙주방어중발휘중요작용.연이,대량적연구증실IL-17여다충자신면역병급염증질병밀절상관.감우IL-17적숙주방어화면역손상적쌍중작용,인문대IL-17/IL-17R신호전도궤제급기생리화병리공능진행료경심입적연구,종이위상관질병적간예화치료제공료신적사로.
Interleukin-17 (IL-17)A is the prototypic member of the IL-17 family,which comprises six members:IL-17A to F.As an important proinflammatory cytokine,IL-17 plays critical roles in host defense by inducing the release of certain chemokines,cytokines and antimicrobial proteins.However,IL-17 has also been found to play important roles in the pathogenesis of various human autoimmune and inflammatory diseases.Recently,important new insights into the composition of IL-17/IL-17 receptor superfamily,the downstream signal transduction pathway of IL-17 and the physiological/pathological function of IL-17 which will provide new ideas for the intervention and treatment for the related diseases.
