CAJ | 학술논문

目的观察牙周基础治疗对2型糖尿病伴牙周炎患者血清及龈沟液中肿瘤坏死因子-α(TNF-α)的浓度、临床牙周状态、血糖控制的影响.方法选取2型糖尿病伴牙周炎患者60例,随机分做牙周基础治疗组(观察组)和不做牙周基础治疗组(对照组),每组各30人.分别在治疗前、治疗后1个月和3个月记录所有患者牙周临床指数:探诊深度(PD),附着丧失(AL)及菌斑指数(PLI),并检测糖化血红蛋白(HbAlc)及血清及龈沟液中TNF-α的含量.结果观察组中PD、PLI和龈沟液中TNF-α含量在治疗后1个月和3个月时均显著降低(P＜0.05),AL和血清中HbAlc及TNF-α含量仅在治疗后3个月显著降低(P＜0.05).对照组的PD,AL,PLI,HbAlc,龈沟液及血清中TNF-α的差异无统计学意义(P＞0.05).结论牙周基础治疗有助于2型糖尿病伴牙周炎患者的血糖控制,牙周状态改变和血清及龈沟液中TNF-α含量下降.
목적 관찰아주기출치료대2형당뇨병반아주염환자혈청급간구액중종류배사인자-α(TNF-α)적농도、림상아주상태、혈당공제적영향.방법 선취2형당뇨병반아주염환자60례,수궤분주아주기출치료조(관찰조)화불주아주기출치료조(대조조),매조각30인.분별재치료전、치료후1개월화3개월기록소유환자아주림상지수:탐진심도(PD),부착상실(AL)급균반지수(PLI),병검측당화혈홍단백(HbAlc)급혈청급간구액중TNF-α적함량.결과 관찰조중PD、PLI화간구액중TNF-α함량재치료후1개월화3개월시균현저강저(P＜0.05),AL화혈청중HbAlc급TNF-α함량부재치료후3개월현저강저(P＜0.05).대조조적PD,AL,PLI,HbAlc,간구액급혈청중TNF-α적차이무통계학의의(P＞0.05).결론 아주기출치료유조우2형당뇨병반아주염환자적혈당공제,아주상태개변화혈청급간구액중TNF-α함량하강.
Objective The aim of this study was to evaluate the effects of basic periodontal therapy on the level of tumor necrosis factor-alpha in serum and gingival crevicular fluid,clinical periodontal measurements,glycemic control in type two diabetic patients (T2DM) with chronic periodontitis.Methods Sixty patients with type two diabetes and chronic periodontitis,randomly divided into basic periodontal therapy group (observation group) and non-basic periodontal therapy group (control group),and each group was 30 patients.All subjects received basic periodontal therapy.Clinical periodontal parameters:probing depth (PD),attachment loss(AL),and plaque index (PLI) were recorded at baseline,1 and 3 months after the treatment,HbA1c and the level of TNF-α in serum and gingival crevicular fluid were measured.Results At 1 and 3 months after treatment,PD,PLI and TNF-α in gingival crevicular fluid significantly reduced (P ＜ 0.05) in observation group,but AL and the concentration of HbAlc and TNF-α in serum reduced significantly 3 months after treatment (P ＜ 0.05),while that of control group had no significant difference after the treatment (P＞0.05).Conclusion The basic periodontal therapy can help to control the glucose level,clinical periodontal improvements and decreases TNF-α in serum and gingival crevicular fluid in type two diabetic patients with periodontitis.