国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
6期
482-486
,共5页
Survivin%b-FG%Ang-1%CD34%大肠癌%免疫组化
Survivin%b-FG%Ang-1%CD34%大腸癌%免疫組化
Survivin%b-FG%Ang-1%CD34%대장암%면역조화
Survivin%b-FGF%Ang-1%CD34%Colorectal cancer%Immunohistochemistry
目的 检测大肠癌组织中Survivin、b-FGF和Ang-1的表达水平,探讨Survivin和b-FGF、Ang-1与大肠癌肿瘤血管生成的关系.方法 采用免疫组织化学方法检测Survivin、b-FGF、Ang-1和CD34在7例肠炎组织、10例肠息肉组织和26例大肠癌组织中的表达.结果 Survivin和Ang-1蛋白在大肠癌组阳性表达率分别为76.9％和80.8％,高于大肠息肉组与肠炎组的表达(P＜0.05).b-FGF蛋白在大肠癌组阳性表达率为73.1％,高于肠炎组(P＜0.05),而与大肠息肉组比较无统计学意义(P＞0.05).CD34蛋白在大肠癌组中的微血管计数(MVD)值为23.69±9.96,高于大肠息肉组与肠炎组.Survivin、b-FGF和Ang-1蛋白阳性表达肿瘤组织中多见肿瘤微血管计数增加,二者呈正相关.Survivin和促血管形成因子b-FGF、Ang-1在大肠癌组织中的表达密切相关.结论 在大肠癌发生、发展中,Survivin、b-FGF、Ang-1于肿瘤血管形成过程中起着重要的协同作用.
目的 檢測大腸癌組織中Survivin、b-FGF和Ang-1的錶達水平,探討Survivin和b-FGF、Ang-1與大腸癌腫瘤血管生成的關繫.方法 採用免疫組織化學方法檢測Survivin、b-FGF、Ang-1和CD34在7例腸炎組織、10例腸息肉組織和26例大腸癌組織中的錶達.結果 Survivin和Ang-1蛋白在大腸癌組暘性錶達率分彆為76.9％和80.8％,高于大腸息肉組與腸炎組的錶達(P＜0.05).b-FGF蛋白在大腸癌組暘性錶達率為73.1％,高于腸炎組(P＜0.05),而與大腸息肉組比較無統計學意義(P＞0.05).CD34蛋白在大腸癌組中的微血管計數(MVD)值為23.69±9.96,高于大腸息肉組與腸炎組.Survivin、b-FGF和Ang-1蛋白暘性錶達腫瘤組織中多見腫瘤微血管計數增加,二者呈正相關.Survivin和促血管形成因子b-FGF、Ang-1在大腸癌組織中的錶達密切相關.結論 在大腸癌髮生、髮展中,Survivin、b-FGF、Ang-1于腫瘤血管形成過程中起著重要的協同作用.
목적 검측대장암조직중Survivin、b-FGF화Ang-1적표체수평,탐토Survivin화b-FGF、Ang-1여대장암종류혈관생성적관계.방법 채용면역조직화학방법검측Survivin、b-FGF、Ang-1화CD34재7례장염조직、10례장식육조직화26례대장암조직중적표체.결과 Survivin화Ang-1단백재대장암조양성표체솔분별위76.9％화80.8％,고우대장식육조여장염조적표체(P＜0.05).b-FGF단백재대장암조양성표체솔위73.1％,고우장염조(P＜0.05),이여대장식육조비교무통계학의의(P＞0.05).CD34단백재대장암조중적미혈관계수(MVD)치위23.69±9.96,고우대장식육조여장염조.Survivin、b-FGF화Ang-1단백양성표체종류조직중다견종류미혈관계수증가,이자정정상관.Survivin화촉혈관형성인자b-FGF、Ang-1재대장암조직중적표체밀절상관.결론 재대장암발생、발전중,Survivin、b-FGF、Ang-1우종류혈관형성과정중기착중요적협동작용.
Objective To investigate the expression of Survivin,basic fibroblast growth factor and angiopoietin-1 in colorectal cancer and delineate the relationship of expression levels of protein with tumor angiogenesis.Methods The expression of Survivin,b-FGF,Ang-1 and CD34 were detected in 7 cases of colitis tissues,10 cases of intestinal polyps and 26 cases of colorectal cancer tissues by immunohistochemical methods.Results In colorectal cancer group,the positive expression rates of Survivin and Ang-1 protein were 76.9％ and 80.8％,respectively,which were significantly higher than that in both colorectal polyps group and colitis group (P＜0.05).In colorectal cancer group,the positive expression rate of b-FGF protein was 73.1％,which was significantly higher than that in colitis group (P ＜ 0.05),but which was not statistical significance in comparison with colorectal polyps group (P ＞ 0.05).In colorectal cancer group,CD34 protein microvessel count was 23.69±9.96,which was significantly higher than that in both colorectal polyps group and colitis group.In colorectal cancer group,the expression of Survivin,b-FGF,Ang-1 protein showed positive correlation with tumor MVD.The expression of Survivin and b-FGF,Ang-1 in colorectal cancer tissues related closely.Conclusion In colorectal cancer development and advancement,Survivin,b-FGF and Ang-1 paly important roles with neovascularization.
