CAJ | 학술논문

自麻疹减毒活疫苗研制成功并广泛使用以来,许多国家有效地控制了麻疹流行.然而在麻疹疫苗使用40多年后,麻疹仍然是引起儿童死亡的主要原因,其中包括免疫系统缺陷和母传抗体对麻疹疫苗免疫应答的干扰作用.由于在麻疹的预防控制方面仍然存在着一些问题,造成了免疫失败,因此近年来对儿童接种麻疹疫苗又出现了很多新的策略,其中加强常规免疫接种和定期开展补充强化免疫活动已在许多国家被证明是控制麻疹发生的有效措施.同时一些新型麻疹疫苗的研制也在应运而生,虽然目前尚未被广泛应用,但却具有很大的应用前景.
자마진감독활역묘연제성공병엄범사용이래,허다국가유효지공제료마진류행.연이재마진역묘사용40다년후,마진잉연시인기인동사망적주요원인,기중포괄면역계통결함화모전항체대마진역묘면역응답적간우작용.유우재마진적예방공제방면잉연존재착일사문제,조성료면역실패,인차근년래대인동접충마진역묘우출현료흔다신적책략,기중가강상규면역접충화정기개전보충강화면역활동이재허다국가피증명시공제마진발생적유효조시.동시일사신형마진역묘적연제야재응운이생,수연목전상미피엄범응용,단각구유흔대적응용전경.
Measles remains a major cause of child mortality despite the availability of a safe and effective live attenuated virus vaccine (LAV).Recent efforts to improve routine vaccination and implement national immunization days have enhanced measles control.One persistent impediment to measles control in many countries remains the inability to successfully immunize young infants due to the immaturity of the immune system and interference of maternal antibodies with immune responses to LAV.Therefore,many strategies are emerging for the development of a vaccine for young infants.As potential improvements,some new vaccines or novel deliveries of reconstituted liquid LAMV have been studied but have never been licensed or widely used.This review concentiates the progress of measles vaccine studies both at home and abroad.