CAJ | 학술논문

IL-22为IL-10家族成员之一.作为一种新型细胞因子,其与自身免疫性疾病关系密切.最近大量证据表明IL-22参与了多种自身免疫性疾病,如系统性红斑狼疮、类风湿性关节炎、多发性硬化、干燥综合征、银屑病等.然而在不同的自身免疫性疾病中IL-22所发挥的作用不尽相同,可能起致病性作用,也可能起保护性作用.因此以IL-22作为靶点为多种自身免疫性疾病的治疗提供了新的思路.
IL-22위IL-10가족성원지일.작위일충신형세포인자,기여자신면역성질병관계밀절.최근대량증거표명IL-22삼여료다충자신면역성질병,여계통성홍반랑창、류풍습성관절염、다발성경화、간조종합정、은설병등.연이재불동적자신면역성질병중IL-22소발휘적작용불진상동,가능기치병성작용,야가능기보호성작용.인차이IL-22작위파점위다충자신면역성질병적치료제공료신적사로.
Interleukin-22(IL-22) is an Interleukin-10(IL-10) family cytokine member.As a new discovered cytokine,it has close relationship with many autoimmune diseases.Recently,there is emerging evidence that IL-22 is involved in the development and pathogenesis of many autoimmune diseases,such as systemic lupus erythematosus (SLE),rheumatoid arthritis (RA),multiple sclerosis (MS),Sjogren syndrome (SS) and psoriasis.However,in different immune diseases,the role of IL-22 plays is not all the same,it may play a pathogenic role,also may play a protective role.Therefore,therapeutics targeting IL-22 may have promise for treating various autoimmune diseases.In this paper,we review the new discovery and different pathogenesis of IL-22 in several autoimmune diseases,as well as discuss its clinical implications and therapeutic potential.