国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
4期
268-270
,共3页
磷脂酰肌醇蛋白聚糖3%肿瘤标志物%基因治疗
燐脂酰肌醇蛋白聚糖3%腫瘤標誌物%基因治療
린지선기순단백취당3%종류표지물%기인치료
Glypican-3%Tumor markers%Gene therapy
原发性肝癌(PHC)是目前世界上最常见的恶性肿瘤之一.肝癌的发生是由化学致癌物、病毒、遗传等多病因作用引起的.其恶性程度高,预后差,进展较快.早期诊断、治疗对肝癌患者的预后至关重要,目前临床诊断主要依靠影像学检查及肿瘤标志物甲胎蛋白(AFP).但AFP的敏感性和特异性均不高.近年来,一种新的肝癌肿瘤学标志物磷脂酰肌醇蛋白聚糖3(GPC3)成为不少国内外学者研究热点,其在肝癌中无论mRNA水平还是蛋白质水平均为高表达,GPC3对PHC的诊断具有较高的敏感性和特异性,其在AFP阴性的肝癌中亦有表达.
原髮性肝癌(PHC)是目前世界上最常見的噁性腫瘤之一.肝癌的髮生是由化學緻癌物、病毒、遺傳等多病因作用引起的.其噁性程度高,預後差,進展較快.早期診斷、治療對肝癌患者的預後至關重要,目前臨床診斷主要依靠影像學檢查及腫瘤標誌物甲胎蛋白(AFP).但AFP的敏感性和特異性均不高.近年來,一種新的肝癌腫瘤學標誌物燐脂酰肌醇蛋白聚糖3(GPC3)成為不少國內外學者研究熱點,其在肝癌中無論mRNA水平還是蛋白質水平均為高錶達,GPC3對PHC的診斷具有較高的敏感性和特異性,其在AFP陰性的肝癌中亦有錶達.
원발성간암(PHC)시목전세계상최상견적악성종류지일.간암적발생시유화학치암물、병독、유전등다병인작용인기적.기악성정도고,예후차,진전교쾌.조기진단、치료대간암환자적예후지관중요,목전림상진단주요의고영상학검사급종류표지물갑태단백(AFP).단AFP적민감성화특이성균불고.근년래,일충신적간암종류학표지물린지선기순단백취당3(GPC3)성위불소국내외학자연구열점,기재간암중무론mRNA수평환시단백질수평균위고표체,GPC3대PHC적진단구유교고적민감성화특이성,기재AFP음성적간암중역유표체.
Primary hepatic carcinoma (PHC) is one of the most common malignancy detection of in the world.There are many etiologys can arouse PHC:chemical carcinogens,virus,inheritance,etc.PHC shows a high malignant degree,poor prognosis and fast progress.Early diagnosis and treatment of PHC is very important for the prognosis of patients,present,clinical diagnosis mainly depends on imaging examinations and the detection of tumor marker:αlpha fetal protein (AFP).However,the sensitivity and specificity of AFP was not satisfied.In recent years,a new tumor marker,glypican-3 (GPC3) has been extensively sttedied.Its mRNA and protein levels in PHC were highly expressed.Detection of GPC3 has higher sensitivity and specificity for the diagnosis of PHC.GPC3 is also expressed in the PHC patients with negative AFP.
