CAJ | 학술논문

B7-H6是近年来发现的共刺激分子B7家族新成员,主要表达于肿瘤组织,B7-H6是B7家族第一个特异表达在肿瘤组织中的成员,能够促进NK细胞的活化,负向调节肿瘤逃逸和固有免疫.目前对于B7-H6与其配体NKp30的相互作用的确切机制尚未完全明确,故对近年来关于B7-H6的分子结构、表达与分布情况,配体分子NKp30与肿瘤的关系研究很有意义.
B7-H6시근년래발현적공자격분자B7가족신성원,주요표체우종류조직,B7-H6시B7가족제일개특이표체재종류조직중적성원,능구촉진NK세포적활화,부향조절종류도일화고유면역.목전대우B7-H6여기배체NKp30적상호작용적학절궤제상미완전명학,고대근년래관우B7-H6적분자결구、표체여분포정황,배체분자NKp30여종류적관계연구흔유의의.
B7-H6 is a new member of immunologlobulin family which has been found recently.B7-H6 expression was detected with a relative abundance in tumor cells of distinct origin,but not in normal tissues.B7-H6 is the first instance of a tumor-specific B7 family member that can directly trigger NK cell activation,this down-regulation is a mechanism whereby a tumor would escape innate immunity.The ligand of B7-H6,as well as the mechanism of the B7-H6 signal pathway,has not been clear yet.Therefore,the lastest finding of structure,the ligand NKp30 and the role of B7-H6/NKp30 in the process of tumor were described in this review.