国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
4期
294-297
,共4页
Toll样受体%药物%信号通路%免疫治疗
Toll樣受體%藥物%信號通路%免疫治療
Toll양수체%약물%신호통로%면역치료
Toll-like receptors%Agent%Signaling pathway%Immune therapy
Toll样受体(TLRs)家族是主要的模式识别受体,能够识别多种人侵的病原体,启动炎性应答通路而调节或控制固有免疫与适应性免疫.一旦TLRs与其特异配体结合后,可激活信号转导级联,在急性炎症反应、细胞信号转导和细胞凋亡中起重要作用.目前临床上有很多靶向TLRs的药物来治疗炎症、免疫疾病以及肿瘤等,因此,深入研究TLRs信号系统与靶向TLR药物的作用机制,有助于拓宽新药研究思路,从而寻找针对性强而有效的治疗药物.
Toll樣受體(TLRs)傢族是主要的模式識彆受體,能夠識彆多種人侵的病原體,啟動炎性應答通路而調節或控製固有免疫與適應性免疫.一旦TLRs與其特異配體結閤後,可激活信號轉導級聯,在急性炎癥反應、細胞信號轉導和細胞凋亡中起重要作用.目前臨床上有很多靶嚮TLRs的藥物來治療炎癥、免疫疾病以及腫瘤等,因此,深入研究TLRs信號繫統與靶嚮TLR藥物的作用機製,有助于拓寬新藥研究思路,從而尋找針對性彊而有效的治療藥物.
Toll양수체(TLRs)가족시주요적모식식별수체,능구식별다충인침적병원체,계동염성응답통로이조절혹공제고유면역여괄응성면역.일단TLRs여기특이배체결합후,가격활신호전도급련,재급성염증반응、세포신호전도화세포조망중기중요작용.목전림상상유흔다파향TLRs적약물래치료염증、면역질병이급종류등,인차,심입연구TLRs신호계통여파향TLR약물적작용궤제,유조우탁관신약연구사로,종이심조침대성강이유효적치료약물.
Toll-like receptors (TLRs) family are pattern-recognition receptors that can be activated by microbial components and initiate innate and adaptive immune responses.Binding of TLRs to its specific ligand activates a variety of downstream cascades,such as acute inflammatory reaction,cell signal transduction and cell death.Recently,there are many agents targeted to TLRs used to treat the inflammation,immune disease and tumor.Therefore,research on the TLRs signaling pathway and action mechanism of TLRs-target agent contributes to develop the new agent that is more specific and efficient.
